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2viu

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Revision as of 08:00, 25 June 2020

INFLUENZA VIRUS HEMAGGLUTININ

Structural highlights

2viu is a 2 chain structure with sequence from I000x and Influenza virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HEMA_I68A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.

Antigen distortion allows influenza virus to escape neutralization.,Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T. Antigen distortion allows influenza virus to escape neutralization. Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2viu"

@@ Line 1: / Line 1: @@
 ==INFLUENZA VIRUS HEMAGGLUTININ==
-<StructureSection load='2viu' size='340' side='right' caption='[[2viu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='2viu' size='340' side='right'caption='[[2viu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2viu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/I000x I000x] and [http://en.wikipedia.org/wiki/Influenza_virus Influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VIU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2viu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/I000x I000x] and [http://en.wikipedia.org/wiki/Influenza_virus Influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VIU FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2viu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2viu OCA], [http://pdbe.org/2viu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2viu RCSB], [http://www.ebi.ac.uk/pdbsum/2viu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2viu ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2viu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2viu OCA], [http://pdbe.org/2viu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2viu RCSB], [http://www.ebi.ac.uk/pdbsum/2viu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2viu ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 30: / Line 30: @@
 ==See Also==
-*[[Hemagglutinin|Hemagglutinin]]
+*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
 == References ==
 <references/>
@@ Line 37: / Line 37: @@
 [[Category: I000x]]
 [[Category: Influenza virus]]
+[[Category: Large Structures]]
 [[Category: Bizebard, T]]
 [[Category: Fleury, D]]

2viu

From Proteopedia

Revision as of 08:00, 25 June 2020

INFLUENZA VIRUS HEMAGGLUTININ

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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