Thymidine kinase
From Proteopedia
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**[[2j9r]] – TK + THM – ''Bacillus anthracis''<BR /> | **[[2j9r]] – TK + THM – ''Bacillus anthracis''<BR /> | ||
**[[1xx6]] – TK + ADP – ''Clostridium acetobutylicum''<br /> | **[[1xx6]] – TK + ADP – ''Clostridium acetobutylicum''<br /> | ||
| - | **[[5x86]] – TtTK + TMP - ''Thermus thermophilus''<br /> | ||
| - | **[[5x8c]] – TtTK + TMP + AMPPCP <br /> | ||
| - | **[[5xb3]] – TtTK + TMP + ADP + ATP<br /> | ||
| - | **[[5x8b]] – AaTK + TMP - ''Aquifex aeolicus''<br /> | ||
| - | **[[5xb3]], [[5xb2]] – AaTK + TMP + ADP<br /> | ||
**[[5fuv]] – TbTK + THM – ''Trypanosoma brucei''<br /> | **[[5fuv]] – TbTK + THM – ''Trypanosoma brucei''<br /> | ||
**[[5fuw]] – TbTK + THM + DTMP<br /> | **[[5fuw]] – TbTK + THM + DTMP<br /> | ||
**[[5fux]], [[5fuy]] – TbTK (mutation) + DTMP<br /> | **[[5fux]], [[5fuy]] – TbTK (mutation) + DTMP<br /> | ||
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| - | *Thymidine kinase complex with inhibitor | ||
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| - | **[[5nq5]], [[5n47]], [[5nrn]], [[5nrq]] – TK + pyrimidine derivative – ''Mycobacterium tuberculosis''<BR /> | ||
*Thymidine kinase complex with feed-back inhibitor | *Thymidine kinase complex with feed-back inhibitor | ||
Revision as of 21:43, 25 September 2018
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3D Structures of thymidine kinase
Updated on 25-September-2018
References
- ↑ Perez-Perez MJ, Priego EM, Hernandez AI, Familiar O, Camarasa MJ, Negri A, Gago F, Balzarini J. Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future. Med Res Rev. 2008 Sep;28(5):797-820. doi: 10.1002/med.20124. PMID:18459168 doi:http://dx.doi.org/10.1002/med.20124
- ↑ He Q, Zhang P, Zou L, Li H, Wang X, Zhou S, Fornander T, Skog S. Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity. Oncol Rep. 2005 Oct;14(4):1013-9. PMID:16142366
- ↑ Saada A, Shaag A, Mandel H, Nevo Y, Eriksson S, Elpeleg O. Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Nat Genet. 2001 Nov;29(3):342-4. PMID:11687801 doi:http://dx.doi.org/10.1038/ng751
- ↑ Kosinska U, Carnrot C, Sandrini MP, Clausen AR, Wang L, Piskur J, Eriksson S, Eklund H. Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding. FEBS J. 2007 Feb;274(3):727-37. PMID:17288553 doi:10.1111/j.1742-4658.2006.05617.x
