Thymidylate synthase

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Line 102: Line 102:
**[[6cdz]] - EcTS + deoxyuridine + UMP<br />
**[[6cdz]] - EcTS + deoxyuridine + UMP<br />
**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
-
**[[4knz]] - EcTS + deoxyuridine derivative + folate derivative<br />
+
**[[6nnr]] - EcTS + deoxyuridine derivative + folate derivative<br />
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<BR />
**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<BR />

Revision as of 13:55, 30 January 2019

Thymidylate synthase complex with dUMP (PDB entry 1tsv)

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3D structures of thymidylate synthase

Updated on 30-January-2019

References

  1. ↑ Kaneda S, Nalbantoglu J, Takeishi K, Shimizu K, Gotoh O, Seno T, Ayusawa D. Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem. 1990 Nov 25;265(33):20277-84. PMID:2243092
  2. ↑ Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett JC, Kaye FJ, Zajac-Kaye M. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell. 2004 Apr;5(4):341-51. PMID:15093541
  3. ↑ Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng. 1996 Jan;9(1):69-75. PMID:9053905
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