6hj4

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'''Unreleased structure'''
 
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The entry 6hj4 is ON HOLD until Paper Publication
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==Crystal structure of Whitewater Arroyo virus GP1 glycoprotein at pH 7.5==
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<StructureSection load='6hj4' size='340' side='right' caption='[[6hj4]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hj4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJ4 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj4 OCA], [http://pdbe.org/6hj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hj4 RCSB], [http://www.ebi.ac.uk/pdbsum/6hj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GLYC_WWAVU GLYC_WWAVU]] Stable signal peptide (SSP) is cleaved but is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational cleavage of GP1 and GP2, glycoprotein transport to the cell plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor. This interaction leads to virion entry into the host cell through the endosomal pathway (By similarity). Glycoprotein G2 is a class I viral fusion protein, that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversable conformational changes induced upon acidification in the endosome (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Bowden, T A]]
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[[Category: Ng, W M]]
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[[Category: Omari, K El]]
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[[Category: Pryce, R]]
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[[Category: Wagner, A]]
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[[Category: Watanabe, Y]]
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[[Category: Zeltina, A]]
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[[Category: Attachment]]
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[[Category: Glycoprotein]]
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[[Category: Viral protein]]

Revision as of 08:16, 10 October 2018

Crystal structure of Whitewater Arroyo virus GP1 glycoprotein at pH 7.5

6hj4, resolution 2.43Å

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