6hl1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide and CDCA== | |
| - | + | <StructureSection load='6hl1' size='340' side='right'caption='[[6hl1]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hl1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HL1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qe6|4qe6]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hl1 OCA], [http://pdbe.org/6hl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hl1 RCSB], [http://www.ebi.ac.uk/pdbsum/6hl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hl1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Kudlinzki, D]] | [[Category: Kudlinzki, D]] | ||
| + | [[Category: Linhard, V L]] | ||
| + | [[Category: Merk, D]] | ||
[[Category: Saxena, K]] | [[Category: Saxena, K]] | ||
[[Category: Schubert-Zsilavecz, M]] | [[Category: Schubert-Zsilavecz, M]] | ||
| - | [[Category: Merk, D]] | ||
[[Category: Schwalbe, H]] | [[Category: Schwalbe, H]] | ||
| + | [[Category: Activator]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Dna-binding]] | ||
| + | [[Category: Nuclear protein]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Repressor]] | ||
Revision as of 06:08, 29 May 2019
Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide and CDCA
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