6mgr

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m (Protected "6mgr" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6mgr is ON HOLD
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==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor Oxanosine monophosphate==
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<StructureSection load='6mgr' size='340' side='right' caption='[[6mgr]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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Authors: Kim, Y., Maltseva, N., Yu, R., Hedstrom, L., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mgr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MGR FirstGlance]. <br>
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Description: Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor Oxanosine monophosphate
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=JQS:5-[(Z)-(aminomethylidene)amino]-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxylic+acid'>JQS</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mgr OCA], [http://pdbe.org/6mgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mgr RCSB], [http://www.ebi.ac.uk/pdbsum/6mgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mgr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/A0A2R4D3F6_CAMJU A0A2R4D3F6_CAMJU]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
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__TOC__
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</StructureSection>
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[[Category: IMP dehydrogenase]]
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[[Category: Structural genomic]]
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[[Category: Hedstrom, L]]
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[[Category: Joachimiak, A]]
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[[Category: Kim, Y]]
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[[Category: Maltseva, N]]
[[Category: Yu, R]]
[[Category: Yu, R]]
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[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
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[[Category: Csgid]]
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[[Category: Maltseva, N]]
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[[Category: Delta cb]]
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[[Category: Kim, Y]]
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[[Category: Impdh]]
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[[Category: Joachimiak, A]]
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[[Category: Oxidoreductase]]
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[[Category: Hedstrom, L]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tim barrel]]

Revision as of 06:06, 24 October 2018

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor Oxanosine monophosphate

6mgr, resolution 1.97Å

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