2qcp

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[[Image:2qcp.jpg|left|200px]]
[[Image:2qcp.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qcp |SIZE=350|CAPTION= <scene name='initialview01'>2qcp</scene>, resolution 1.000&Aring;
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The line below this paragraph, containing "STRUCTURE_2qcp", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AG:SILVER+ION'>AG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= cusF, cusX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_2qcp| PDB=2qcp | SCENE= }}
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|RELATEDENTRY=[[1zeq|1zeq]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qcp OCA], [http://www.ebi.ac.uk/pdbsum/2qcp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qcp RCSB]</span>
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}}
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'''1.0 A Structure of CusF-Ag(I) residues 10-88 from Escherichia coli'''
'''1.0 A Structure of CusF-Ag(I) residues 10-88 from Escherichia coli'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Loftin, I R.]]
[[Category: Loftin, I R.]]
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[[Category: beta barrel]]
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[[Category: Beta barrel]]
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[[Category: copper-binding]]
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[[Category: Copper-binding]]
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[[Category: metal binding protein]]
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[[Category: Metal binding protein]]
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[[Category: metal resistance]]
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[[Category: Metal resistance]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: metalloprotein]]
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[[Category: Metalloprotein]]
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[[Category: ob-fold]]
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[[Category: Ob-fold]]
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[[Category: periplasmic]]
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[[Category: Periplasmic]]
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[[Category: silver-binding]]
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[[Category: Silver-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:44:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:47:51 2008''
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Revision as of 11:44, 4 May 2008

Image:2qcp.jpg

Template:STRUCTURE 2qcp

1.0 A Structure of CusF-Ag(I) residues 10-88 from Escherichia coli


Overview

Elevated levels of copper or silver ions in the environment are an immediate threat to many organisms. Escherichia coli is able to resist the toxic effects of these ions through strictly limiting intracellular levels of Cu(I) and Ag(I). The CusCFBA system is one system in E. coli responsible for copper/silver tolerance. A key component of this system is the periplasmic copper/silver-binding protein, CusF. Here the X-ray structure and XAS data on the CusF-Ag(I) and CusF-Cu(I) complexes, respectively, are reported. In the CusF-Ag(I) structure, Ag(I) is coordinated by two methionines and a histidine, with a nearby tryptophan capping the metal site. EXAFS measurements on the CusF-Cu(I) complex show a similar environment for Cu(I). The arrangement of ligands effectively sequesters the metal from its periplasmic environment and thus may play a role in protecting the cell from the toxic ion.

About this Structure

2QCP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Unusual Cu(I)/Ag(I) coordination of Escherichia coli CusF as revealed by atomic resolution crystallography and X-ray absorption spectroscopy., Loftin IR, Franke S, Blackburn NJ, McEvoy MM, Protein Sci. 2007 Oct;16(10):2287-93. PMID:17893365 Page seeded by OCA on Sun May 4 14:44:17 2008

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