2qfi

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[[Image:2qfi.gif|left|200px]]
[[Image:2qfi.gif|left|200px]]
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{{Structure
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|PDB= 2qfi |SIZE=350|CAPTION= <scene name='initialview01'>2qfi</scene>, resolution 3.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2qfi", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|GENE= fieF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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{{STRUCTURE_2qfi| PDB=2qfi | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfi OCA], [http://www.ebi.ac.uk/pdbsum/2qfi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qfi RCSB]</span>
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'''Structure of the zinc transporter YiiP'''
'''Structure of the zinc transporter YiiP'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Lu, M.]]
[[Category: Lu, M.]]
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[[Category: transport protein]]
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[[Category: Transport protein]]
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[[Category: zinc transporter]]
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[[Category: Zinc transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:52:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:48:49 2008''
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Revision as of 11:52, 4 May 2008

Image:2qfi.gif

Template:STRUCTURE 2qfi

Structure of the zinc transporter YiiP


Overview

YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange across the inner membrane of Escherichia coli. Mammalian homologs of YiiP play critical roles in zinc homeostasis and cell signaling. Here, we report the x-ray structure of YiiP in complex with zinc at 3.8 angstrom resolution. YiiP is a homodimer held together in a parallel orientation through four Zn2+ ions at the interface of the cytoplasmic domains, whereas the two transmembrane domains swing out to yield a Y-shaped structure. In each protomer, the cytoplasmic domain adopts a metallochaperone-like protein fold; the transmembrane domain features a bundle of six transmembrane helices and a tetrahedral Zn2+ binding site located in a cavity that is open to both the membrane outer leaflet and the periplasm.

About this Structure

2QFI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the zinc transporter YiiP., Lu M, Fu D, Science. 2007 Sep 21;317(5845):1746-8. Epub 2007 Aug 23. PMID:17717154 Page seeded by OCA on Sun May 4 14:52:30 2008

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