2wpu

From Proteopedia

(Difference between revisions)

Revision as of 08:00, 4 November 2020

Chaperoned ruthenium metallodrugs that recognize telomeric DNA

Structural highlights

2wpu is a 1 chain structure with sequence from As 4.1583. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Related:	1swh, 2bc3, 1vwq, 1sre, 1swf, 2rtb, 1lcw, 1hxz, 1swp, 1rxj, 1swe, 1mm9, 2rto, 1swa, 2rtr, 2rtd, 1stp, 1n43, 2izh, 1sri, 1slf, 1swc, 1vwr, 1swl, 1ndj, 1str, 1slg, 1vwm, 1swd, 1swq, 1swu, 1i9h, 1swj, 2rtj, 2rtl, 2iza, 1vwn, 1vwk, 1vwg, 1moy, 1sts, 1hqq, 1vwi, 2izg, 1swg, 2izb, 1swk, 2izk, 1luq, 1sws, 1n4j, 2izd, 1lcv, 1swt, 1df8, 1vwl, 1vwb, 2rtk, 1srj, 1kl3, 2rti, 2izf, 1swr, 2rth, 2rtm, 2izi, 1vwf, 1vwh, 1pts, 1mk5, 1hxl, 2f01, 1vwd, 1nc9, 1sle, 1vwj, 2ize, 2rtf, 2rtp, 1n9y, 1n9m, 1hy2, 1lcz, 1nqm, 1vwa, 2izl, 1kl5, 2izc, 1mep, 1sld, 1rxh, 1rsu, 1vwc, 1nbx, 1srh, 2izj, 1rst, 1kff, 1srg, 1vwe, 2rtg, 1rxk, 1kl4, 1srf, 2rtq, 2rte, 1swb, 1vwo, 2rta, 2rtc, 2rtn, 1swo, 1swn, 1n7y, 1vwp
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).

Publication Abstract from PubMed

The mode of action of precious metal anticancer metallodrugs is generally believed to involve DNA as a target. However, the poor specificity of such drugs often requires high doses and leads to undesirable side-effects. With the aim of improving the specificity of a ruthenium piano-stool complex towards DNA, we employed a presenter protein strategy based on the biotin-avidin technology. Guided by the X-ray structure of the assembly of streptavidin and a biotinylated piano-stool, we explored the formation of metallodrug-mediated ternary complexes with the presenter protein and DNA. The assemblies bound more strongly to telomere G-quadruplexes than to double-stranded DNA; chemo-genetic modifications (varying the complex or mutating the protein) modulated binding to these targets. We suggest that rational targeting of small molecules by presenter proteins could be exploited to bind metallodrugs to preferred macromolecular targets.

Chemo-Genetic Optimization of DNA Recognition by Metallodrugs using a Presenter-Protein Strategy.,Zimbron JM, Sardo A, Heinisch T, Wohlschlager T, Gradinaru J, Massa C, Schirmer T, Creus M, Ward TR Chemistry. 2010 Sep 28. PMID:20878805^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zimbron JM, Sardo A, Heinisch T, Wohlschlager T, Gradinaru J, Massa C, Schirmer T, Creus M, Ward TR. Chemo-Genetic Optimization of DNA Recognition by Metallodrugs using a Presenter-Protein Strategy. Chemistry. 2010 Sep 28. PMID:20878805 doi:10.1002/chem.201001573

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wpu"

@@ Line 1: / Line 1: @@
 ==Chaperoned ruthenium metallodrugs that recognize telomeric DNA==
-<StructureSection load='2wpu' size='340' side='right' caption='[[2wpu]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
+<StructureSection load='2wpu' size='340' side='right'caption='[[2wpu]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WPU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WPU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WPU FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KYT:(3AS,4S,6AR)-4-(5-((3R,4R)-3,4-DIAMINOPYRROLIDIN-1-YL)-5-OXOPENTYL)TETRAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-2(3H)-ONE-P-CYMENE-CHLORO-RUTHENIUM(III)'>KYT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KYT:(3AS,4S,6AR)-4-(5-((3R,4R)-3,4-DIAMINOPYRROLIDIN-1-YL)-5-OXOPENTYL)TETRAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-2(3H)-ONE-P-CYMENE-CHLORO-RUTHENIUM(III)'>KYT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1swh|1swh]], [[2bc3|2bc3]], [[1vwq|1vwq]], [[1sre|1sre]], [[1swf|1swf]], [[2rtb|2rtb]], [[1lcw|1lcw]], [[1hxz|1hxz]], [[1swp|1swp]], [[1rxj|1rxj]], [[1swe|1swe]], [[1mm9|1mm9]], [[2rto|2rto]], [[1swa|1swa]], [[2rtr|2rtr]], [[2rtd|2rtd]], [[1stp|1stp]], [[1n43|1n43]], [[2izh|2izh]], [[1sri|1sri]], [[1slf|1slf]], [[1swc|1swc]], [[1vwr|1vwr]], [[1swl|1swl]], [[1ndj|1ndj]], [[1str|1str]], [[1slg|1slg]], [[1vwm|1vwm]], [[1swd|1swd]], [[1swq|1swq]], [[1swu|1swu]], [[1i9h|1i9h]], [[1swj|1swj]], [[2rtj|2rtj]], [[2rtl|2rtl]], [[2iza|2iza]], [[1vwn|1vwn]], [[1vwk|1vwk]], [[1vwg|1vwg]], [[1moy|1moy]], [[1sts|1sts]], [[1hqq|1hqq]], [[1vwi|1vwi]], [[2izg|2izg]], [[1swg|1swg]], [[2izb|2izb]], [[1swk|1swk]], [[2izk|2izk]], [[1luq|1luq]], [[1sws|1sws]], [[1n4j|1n4j]], [[2izd|2izd]], [[1lcv|1lcv]], [[1swt|1swt]], [[1df8|1df8]], [[1vwl|1vwl]], [[1vwb|1vwb]], [[2rtk|2rtk]], [[1srj|1srj]], [[1kl3|1kl3]], [[2rti|2rti]], [[2izf|2izf]], [[1swr|1swr]], [[2rth|2rth]], [[2rtm|2rtm]], [[2izi|2izi]], [[1vwf|1vwf]], [[1vwh|1vwh]], [[1pts|1pts]], [[1mk5|1mk5]], [[1hxl|1hxl]], [[2f01|2f01]], [[1vwd|1vwd]], [[1nc9|1nc9]], [[1sle|1sle]], [[1vwj|1vwj]], [[2ize|2ize]], [[2rtf|2rtf]], [[2rtp|2rtp]], [[1n9y|1n9y]], [[1n9m|1n9m]], [[1hy2|1hy2]], [[1lcz|1lcz]], [[1nqm|1nqm]], [[1vwa|1vwa]], [[2izl|2izl]], [[1kl5|1kl5]], [[2izc|2izc]], [[1mep|1mep]], [[1sld|1sld]], [[1rxh|1rxh]], [[1rsu|1rsu]], [[1vwc|1vwc]], [[1nbx|1nbx]], [[1srh|1srh]], [[2izj|2izj]], [[1rst|1rst]], [[1kff|1kff]], [[1srg|1srg]], [[1vwe|1vwe]], [[2rtg|2rtg]], [[1rxk|1rxk]], [[1kl4|1kl4]], [[1srf|1srf]], [[2rtq|2rtq]], [[2rte|2rte]], [[1swb|1swb]], [[1vwo|1vwo]], [[2rta|2rta]], [[2rtc|2rtc]], [[2rtn|2rtn]], [[1swo|1swo]], [[1swn|1swn]], [[1n7y|1n7y]], [[1vwp|1vwp]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wpu OCA], [http://pdbe.org/2wpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wpu RCSB], [http://www.ebi.ac.uk/pdbsum/2wpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wpu ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wpu OCA], [http://pdbe.org/2wpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wpu RCSB], [http://www.ebi.ac.uk/pdbsum/2wpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wpu ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 21: @@
 ==See Also==
-*[[Avidin|Avidin]]
+*[[Avidin 3D structures|Avidin 3D structures]]
 == References ==
 <references/>
@@ Line 27: / Line 27: @@
 </StructureSection>
 [[Category: As 4 1583]]
+[[Category: Large Structures]]
 [[Category: Creus, M]]
 [[Category: Gradinaru, J]]

2wpu

From Proteopedia

Revision as of 08:00, 4 November 2020

Chaperoned ruthenium metallodrugs that recognize telomeric DNA

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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