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2mit
From Proteopedia
(Difference between revisions)
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==Solution structure of oxidized dimeric form of human defensin 5== | ==Solution structure of oxidized dimeric form of human defensin 5== | ||
| - | <StructureSection load='2mit' size='340' side='right' caption='[[2mit]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2mit' size='340' side='right'caption='[[2mit]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mit]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2mit]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIT FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2lxz|2lxz]], [[1zmp|1zmp]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lxz|2lxz]], [[1zmp|1zmp]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DEF5, DEFA5 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DEF5, DEFA5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mit OCA], [https://pdbe.org/2mit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mit RCSB], [https://www.ebi.ac.uk/pdbsum/2mit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mit ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref> |
==See Also== | ==See Also== | ||
| - | *[[Defensin|Defensin]] | + | *[[Defensin 3D structures|Defensin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Nolan, E M]] | [[Category: Nolan, E M]] | ||
[[Category: Wagner, G]] | [[Category: Wagner, G]] | ||
Revision as of 15:15, 2 June 2021
Solution structure of oxidized dimeric form of human defensin 5
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