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Pseudouridine synthase

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<StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA and pseudouridine monophosphate [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
<StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA and pseudouridine monophosphate [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
== Function ==
== Function ==
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'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine<ref>PMID:14566049</ref>. PUS are active in the ribosomal large subunit (Rlu) and ribosomal small subunit (Rsu). '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme.
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'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine<ref>PMID:14566049</ref>. PUS are active in the ribosomal large subunit [[Ribosomal large subunit pseudouridine synthase]] and ribosomal small subunit [[Ribosomal small subunit pseudouridine synthase]]. '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme.
== Structural highlights ==
== Structural highlights ==
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**[[1zl3]] - EcTruB (mutant) + stem-loop RNA<BR />
**[[1zl3]] - EcTruB (mutant) + stem-loop RNA<BR />
**[[2nqp]], [[2nr0]], [[2nre]] – EcTruA + Leu-tRNA<BR />
**[[2nqp]], [[2nr0]], [[2nre]] – EcTruA + Leu-tRNA<BR />
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**[[3hjw]], [[3lwo]], [[3lwp]], [[3lwq]], [[3lwr]], [[3lwv]] – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA – ''Pyrococcus furiosus''<BR />
 
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**[[3mqk]] - PfPUS Cbf5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA<BR />
 
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**[[3hjy]] - PfPUS Cbf5 + ribosome biogenesis protein NOP10 + RNA<BR />
 
**[[1ze2]] - TmPUS B + RNA<BR />
**[[1ze2]] - TmPUS B + RNA<BR />
**[[2ab4]] - TmPUS B (mutant) + RNA<BR />
**[[2ab4]] - TmPUS B (mutant) + RNA<BR />
**[[1r3e]], [[1r3f]] - EcTruB + RNA<BR />
**[[1r3e]], [[1r3f]] - EcTruB + RNA<BR />
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*Probable tRNA pseudouridine synthase
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**[[3hjw]], [[3lwo]], [[3lwp]], [[3lwq]], [[3lwr]], [[3lwv]], [[3hax]] – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA – ''Pyrococcus furiosus''<BR />
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**[[3hay]] – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA + small nuclear RNP protein<BR />
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**[[2hvy]] – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA + small nuclear RNP protein + small nuclear RNP Gar1-like protein<BR />
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**[[3mqk]] - PfPUS Cbf5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA<BR />
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**[[2rfk]] - PfPUS Cbf5 (mutant) + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA<BR />
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**[[2ey4]] - PfPUS Cbf5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein <BR />
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**[[3hjy]] - PfPUS Cbf5 + ribosome biogenesis protein NOP10 + RNA<BR />
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**[[2apo]] - PfPUS Cbf5 + ribosome biogenesis protein NOP10 - ''Methanocaldococcus jannaschii''<BR />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 19:08, 27 September 2018

tRNA pseudouridine synthase complex with RNA and pseudouridine monophosphate 1ze2

Drag the structure with the mouse to rotate

3D Structures of tRNA pseudouridine synthase

Updated on 27-September-2018

References

  1. ↑ Pan H, Agarwalla S, Moustakas DT, Finer-Moore J, Stroud RM. Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12648-53. Epub 2003 Oct 17. PMID:14566049 doi:10.1073/pnas.2135585100
  2. ↑ Phannachet K, Huang RH. Conformational change of pseudouridine 55 synthase upon its association with RNA substrate. Nucleic Acids Res. 2004 Feb 27;32(4):1422-9. Print 2004. PMID:14990747 doi:10.1093/nar/gkh287
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