Tyrosine phosphatase

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Line 81: Line 81:
**[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br />
**[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br />
**[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR />
**[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR />
-
**[[4gs0]] – hPTPN6 catalytic domain + peptide<br />
+
**[[4gs0]], [[1fpr]] – hPTPN6 catalytic domain + peptide<br />
**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />
**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />
**[[4icz]] – hPTPN9 catalytic domain + peptide<br />
**[[4icz]] – hPTPN9 catalytic domain + peptide<br />
Line 94: Line 94:
**[[5lm2]] – hRPTP23 residues 362-713 + UBAP-1 peptide<br />
**[[5lm2]] – hRPTP23 residues 362-713 + UBAP-1 peptide<br />
**[[3rz2]] - rPTP 4A1 + peptide<br />
**[[3rz2]] - rPTP 4A1 + peptide<br />
-
**[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br />
 
**[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide<br />
**[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide<br />
**[[1vj6]] – mPTP PDZ2 domain + APC C terminal – NMR<br />
**[[1vj6]] – mPTP PDZ2 domain + APC C terminal – NMR<br />
Line 132: Line 131:
**[[2b4s]] - hPTP1B catalytic domain + insulin receptor<br />
**[[2b4s]] - hPTP1B catalytic domain + insulin receptor<br />
**[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br />
**[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br />
-
**[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br />
 
-
**[[1jyo]] – StPTP + secretion chaperone SICP<br />
 
**[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br />
**[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br />
-
**[[5lxq]] – mPTP + CNNM2<br />
 
**[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br />
**[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br />
**[[5k22]] – hPTP PRL-2 (mutant) + CNNM3<br />
**[[5k22]] – hPTP PRL-2 (mutant) + CNNM3<br />
**[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br />
**[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br />
 +
**[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br />
 +
**[[1jyo]] – StPTP + secretion chaperone SICP<br />
 +
**[[5lxq]] – mPTP + CNNM2<br />
**[[5mmz]] – mPTP 4A1 + CNNM2<br />
**[[5mmz]] – mPTP 4A1 + CNNM2<br />
**[[4zj7]] – yPTPN CDC14 C terminal + importin<br />
**[[4zj7]] – yPTPN CDC14 C terminal + importin<br />
Line 166: Line 165:
**[[1jln]], [[2a8b]] - mRPTP-R catalytic domain<br />
**[[1jln]], [[2a8b]] - mRPTP-R catalytic domain<br />
**[[3sr9]] - mRPTP-σ residues 1326 – 1901<br />
**[[3sr9]] - mRPTP-σ residues 1326 – 1901<br />
-
**[[2nv5]] – RPRP - rat<br />
+
**[[2nv5]] – rRPRP<br />
**[[2yd4]] - cRPTP-σ Ig1-2 domain – chicken<br />
**[[2yd4]] - cRPTP-σ Ig1-2 domain – chicken<br />
**[[2yd1]], [[2yd2]], [[3pxj]] – DmRPTP Ig1-2 domain – ''Drosophila melanogaster''<br />
**[[2yd1]], [[2yd2]], [[3pxj]] – DmRPTP Ig1-2 domain – ''Drosophila melanogaster''<br />
Line 176: Line 175:
**[[2i3r]], [[2i5x]] - hRPTP-β catalytic domain<br />
**[[2i3r]], [[2i5x]] - hRPTP-β catalytic domain<br />
**[[2hc1]], [[2hc2]] - hRPTP-β catalytic domain (mutant) <br />
**[[2hc1]], [[2hc2]] - hRPTP-β catalytic domain (mutant) <br />
-
**[[2h4v]], [[2pbn]] – hRPTP-γ domain 1<br />
+
**[[2h4v]], [[2pbn]], [[3qcb]] – hRPTP-γ domain 1<br />
**[[3qcn]] - hRPTP-γ domain 1 (mutant) <br />
**[[3qcn]] - hRPTP-γ domain 1 (mutant) <br />
**[[2nlk]] - hRPTP-γ catalytic domain<br />
**[[2nlk]] - hRPTP-γ catalytic domain<br />
Line 219: Line 218:
**[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br />
**[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br />
**[[2h03]] - hRPTP-β catalytic domain (mutant) + inhibitor<br />
**[[2h03]] - hRPTP-β catalytic domain (mutant) + inhibitor<br />
-
**[[2hy3]], [[3qcb]], [[3qcc]], [[3qcd]] - hRPTP-γ domain 1 + VO4<BR />
+
**[[2hy3]], [[3qcc]], [[3qcd]] - hRPTP-γ domain 1 + VO4<BR />
**[[3qce]], [[3qcf]], [[3qcg]], [[3qch]], [[3qci]], [[3qcj]], [[3qck]] - hRPTP-γ domain 1 + inhibitor<br />
**[[3qce]], [[3qcf]], [[3qcg]], [[3qch]], [[3qci]], [[3qcj]], [[3qck]] - hRPTP-γ domain 1 + inhibitor<br />
**[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br />
**[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br />
Line 226: Line 225:
**[[3kld]] - mRPTP-γ CA-like domain + contactin 4<br />
**[[3kld]] - mRPTP-γ CA-like domain + contactin 4<br />
**[[4rca]], [[4y61]] - hRPTP-δ + SLITRK1<br />
**[[4rca]], [[4y61]] - hRPTP-δ + SLITRK1<br />
-
**[[5y32]], [[4yfd]], [[4yh7]] - hRPTP-δ + IL1RAPL1<br />
+
**[[5y32]], [[4yfd]], [[4yh7]], [[5wy8]] - hRPTP-δ + IL1RAPL1<br />
**[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br />
**[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br />
**[[3s97]] - hRPTP-ζ CA-like domain + congtactin Ig domains<br />
**[[3s97]] - hRPTP-ζ CA-like domain + congtactin Ig domains<br />
**[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br />
**[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br />
-
*'''Dual-specificity tyrosine phosphatase'''
+
*'''Dual-specificity tyrosine phosphatase or Dual-specificity protein phosphatase''' See [[MAP kinase phosphatase]].
-
 
+
-
**[[1t3k]] – DUSP (mutant) – ''Arabidopsis thaliana''<br />
+
-
**[[6apx]] – hDUSP-1/MBP + monobody<br />
+
-
**[[2g6z]] – hDUSP-5<br />
+
-
**[[4y2e]] – hDUSP-7 (mutant)<br />
+
-
**[[3lj8]] – hDUSP-9<br />
+
-
**[[4jnb]], [[4ki9]] – hDUSP-12 catalytic domain (mutant)<br />
+
-
**[[2wgp]] – hDUSP-14 residues 2-191<br />
+
-
**[[4yr8]] – hDUSP-16 + MAPK8<br />
+
-
**[[4d3p]], [[4d3q]], [[4d3r]] – hDUSP-19 (mutant)<br />
+
-
**[[4woh]] – hDUSP-22 (mutant) + nitrophenolphosphate<br />
+
-
**[[5gtj]] – hDUSP-26<br />
+
*'''Class II'''
*'''Class II'''
Line 252: Line 239:
**[[2cwd]] – LMW-PTP – ''Thermus thermophilus''<br />
**[[2cwd]] – LMW-PTP – ''Thermus thermophilus''<br />
**[[5got]] – LMW-PTP – ''Streptococcus pyogenes''<br />
**[[5got]] – LMW-PTP – ''Streptococcus pyogenes''<br />
 +
**[[5z3m]] – LMW-PTP – ''Vibrio cholerae''<br />
**[[1phr]] - bLMW-PTP<br />
**[[1phr]] - bLMW-PTP<br />
-
**[[1xww]], [[4z99]] - hLMW-PTP <br />
+
**[[1xww]], [[4z99]], [[5pnt]] - hLMW-PTP <br />
**[[1u2p]], [[2luo]] – MtLMW-PTP – ''Mycobacterium tuberculosis''<br />
**[[1u2p]], [[2luo]] – MtLMW-PTP – ''Mycobacterium tuberculosis''<br />
**[[2oz5]] – MtLMW-PTP + inhibitor<br />
**[[2oz5]] – MtLMW-PTP + inhibitor<br />

Revision as of 23:03, 1 October 2018

Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, 3i7z

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3D Structures of tyrosine phosphatase

Updated on 01-October-2018

References

  1. ↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
  2. ↑ Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, Cirri P. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016 Oct;1864(10):1339-55. doi:, 10.1016/j.bbapap.2016.07.001. Epub 2016 Jul 13. PMID:27421795 doi:http://dx.doi.org/10.1016/j.bbapap.2016.07.001
  3. ↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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