Tyrosine phosphatase
From Proteopedia
(Difference between revisions)
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<StructureSection load='3i7z' size='340' side='right' caption='Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]]' scene='' > | <StructureSection load='3i7z' size='340' side='right' caption='Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]]' scene='' > | ||
| - | '''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways<ref>PMID:14625689</ref>. PTPs are divided to 4 subfamilies. '''PTP class I''' contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. '''PTP class II''' are low moleculat weight PTP which dephosphorylate a number of growth factors and modulate their signalling processes<ref>PMID:27421795</ref>. '''PTP class III''' contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP.<br />For details on ''Yersinia'' PTP see [[Yersinia YopH]].<br />For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]]. | + | '''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways<ref>PMID:14625689</ref>. PTPs are divided to 4 subfamilies. '''PTP class I''' contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. '''PTP class II''' are low moleculat weight PTP which dephosphorylate a number of growth factors and modulate their signalling processes<ref>PMID:27421795</ref>. '''PTP class III''' contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP. '''Non-receptor type PTPs''' are coded by the PTPN genes. <br />For details on ''Yersinia'' PTP see [[Yersinia YopH]].<br />For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]]. |
== Disease == | == Disease == | ||
PTP mutations are involved in cancers<ref>PMID:16557282</ref>. | PTP mutations are involved in cancers<ref>PMID:16557282</ref>. | ||
| + | == 3D Structures of tyrosine phosphatase == | ||
| + | [[Tyrosine phosphatase 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of tyrosine phosphatase == | == 3D Structures of tyrosine phosphatase == | ||
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**[[5k9v]] – hPTPN1 - human<br /> | **[[5k9v]] – hPTPN1 - human<br /> | ||
**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 (mutant)<br /> | **[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 (mutant)<br /> | ||
| - | **[[1a5y]], [[2hnp]], [[2hnq]], [[1oem]], [[1oeo]], [[1oes]], [[1oet]], [[1oeu]], [[1oev]], [[1sug]], [[2cm2]], [[2cm3]], [[3eu0]], [[3i80]], [[3a5j]], [[1bzc]], [[6b8e]], [[6b8t]], [[6b8x]], [[6b90]] - hPTP1B catalytic domain <br /> | + | **[[1a5y]], [[2hnp]], [[2hnq]], [[1oem]], [[1oeo]], [[1oes]], [[1oet]], [[1oeu]], [[1oev]], [[1sug]], [[2cm2]], [[2cm3]], [[3eu0]], [[3i80]], [[3a5j]], [[1bzc]], [[6b8e]], [[6b8t]], [[6b8x]], [[6b90]], [[6ntp]] - hPTP1B catalytic domain 1-321<br /> |
| - | **[[1gfy]], [[1i57]], [[1pa1]], [[2f6f]], [[3a5k]], [[3zv2]], [[3qkp]], [[3qkq]], [[6bai]] - hPTP1B catalytic domain (mutant) <br /> | + | **[[1gfy]], [[1i57]], [[1pa1]], [[2f6f]], [[3a5k]], [[3zv2]], [[3qkp]], [[3qkq]], [[6bai]], [[6olq]], [[6olv]], [[6omy]], [[6pfw]], [[6pg0]], [[6pgt]], [[6pha]], [[6phs]], [[6cwv]], [[6cwu]] - hPTP1B catalytic domain (mutant) <br /> |
| + | **[[3pdz]] - hPTP-1E PDZ2 domain – NMR<br /> | ||
**[[2b49]] – hPTPN3 catalytic domain<br /> | **[[2b49]] – hPTPN3 catalytic domain<br /> | ||
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br /> | **[[4qun]] – hPTPN3 catalytic domain (mutant) <br /> | ||
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**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR<BR /> | **[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR<BR /> | ||
**[[1rxd]] - hPTP IVA-1<br /> | **[[1rxd]] - hPTP IVA-1<br /> | ||
| + | **[[1gwz]], [[2b3o]] – hPTP SHP-1 catalytic domain<br /> | ||
| + | **[[1x6c]] - hPTP SHP-1 SH2 domain 105-220 – NMR<br /> | ||
| + | **[[6cmq]] - hPTP SHP-2 106-529<br /> | ||
| + | 2shp, [[6ihz]], [[6crf]], [[6cmp]] - hPTP SHP-2 (mutant)**[[1c0e]] – bPTP (mutant) – bovine<br /> | ||
**[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR<BR /> | **[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR<BR /> | ||
**[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR<BR /> | **[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR<BR /> | ||
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**[[1zck]], [[1x24]] – rPTP 4A1 – rat<br /> | **[[1zck]], [[1x24]] – rPTP 4A1 – rat<br /> | ||
**[[3i36]] – rPTP-η catalytic domain<br /> | **[[3i36]] – rPTP-η catalytic domain<br /> | ||
| - | **[[ | + | **[[2pi7]] – cPTP CRYP-2 catalytic domain - chicken<br /> |
**[[1d1p]], [[2j16]], [[6byf]] – yPTP - yeast<br /> | **[[1d1p]], [[2j16]], [[6byf]] – yPTP - yeast<br /> | ||
**[[2j17]] - yPTP (mutant)<br /> | **[[2j17]] - yPTP (mutant)<br /> | ||
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**[[1g4w]] – StPTP – ''Salmonella typhimurium''<br /> | **[[1g4w]] – StPTP – ''Salmonella typhimurium''<br /> | ||
**[[2i6i]], [[3ro1]] – SsPTP – ''Sulfolobus solfataricus''<br /> | **[[2i6i]], [[3ro1]] – SsPTP – ''Sulfolobus solfataricus''<br /> | ||
| - | **[[2pi7]] – cPTP CRYP-2 catalytic domain <br /> | ||
**[[2z72]], [[1v73]], [[2zbm]] – PTP residues 22-361 – ''Shewanella''<br /> | **[[2z72]], [[1v73]], [[2zbm]] – PTP residues 22-361 – ''Shewanella''<br /> | ||
**[[3js5]], [[3jvi]] – EhPTP – ''Entamoeba histolytica''<br /> | **[[3js5]], [[3jvi]] – EhPTP – ''Entamoeba histolytica''<br /> | ||
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**[[1bzh]] - hPTP1B catalytic domain + fluoromalonyl tyrosine peptide<br /> | **[[1bzh]] - hPTP1B catalytic domain + fluoromalonyl tyrosine peptide<br /> | ||
**[[1bzj]] - hPTP1B catalytic domain + phosphotyrosine mimetic<br /> | **[[1bzj]] - hPTP1B catalytic domain + phosphotyrosine mimetic<br /> | ||
| - | **[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) + peptide<br /> | + | **[[6hks]] – hPTPN3 489-597 + peptide<br /> |
| + | **[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) 628-909 + peptide<br /> | ||
**[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br /> | **[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br /> | ||
**[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR /> | **[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR /> | ||
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**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br /> | **[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br /> | ||
**[[5crv]], [[5mk3]], [[5mk2]], [[5mk1]], [[5mk0]], [[5mjy]] – hRPTP23 domain Bro + STAM2 peptide<br /> | **[[5crv]], [[5mk3]], [[5mk2]], [[5mk1]], [[5mk0]], [[5mjy]] – hRPTP23 domain Bro + STAM2 peptide<br /> | ||
| - | **[[ | + | **[[5lm1]] – hRPTP23 residues 362-713 + UBAP-1 peptide<br /> |
| + | **[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br /> | ||
| + | **[[6roy]] - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITIM peptide <br /> | ||
| + | **[[6roz]] - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITSM peptide <br /> | ||
| + | **[[6r5g]] - hPTP SHP-2 SH2 domain 105-220 + ITSM peptide – NMR<br /> | ||
**[[3rz2]] - rPTP 4A1 + peptide<br /> | **[[3rz2]] - rPTP 4A1 + peptide<br /> | ||
**[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide<br /> | **[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide<br /> | ||
| - | **[[1vj6]] – mPTP PDZ2 domain + APC C terminal – NMR<br /> | + | **[[1vj6]] – mPTP-BL PDZ2 domain + APC C terminal – NMR<br /> |
| - | **[[ | + | **[[6gbe]] – mPTPN13 PDZ3 domain + PRK2 peptide – NMR<br /> |
**[[5xw5]] – yPTPN CDC14 + SWI6 peptide<br /> | **[[5xw5]] – yPTPN CDC14 + SWI6 peptide<br /> | ||
| + | **[[6g86]] – yPTPN CDC14 + SIC1 peptide<br /> | ||
| + | **[[6g85]], [[6g84]] – yPTPN CDC14 + CBK1 peptide<br /> | ||
| + | **[[2dxp]], [[2i6o]] – SsPTP (mutant) + peptide<br /> | ||
*Non-receptor type PTP complex with small molecule | *Non-receptor type PTP complex with small molecule | ||
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**[[1ptv]], [[1pty]] - hPTP1B catalytic domain (mutant) + phosphotyrosine<br /> | **[[1ptv]], [[1pty]] - hPTP1B catalytic domain (mutant) + phosphotyrosine<br /> | ||
**[[1aax]] - hPTP1B catalytic domain (mutant) + bis-phosphophenyl methane<br /> | **[[1aax]] - hPTP1B catalytic domain (mutant) + bis-phosphophenyl methane<br /> | ||
| - | **[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]], [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]], [[4y14]], [[6bmr]], [[6bmv]], [[6bmx]], [[6bmu]], [[6bmw]], [[6bmy]], [[5t19]], [[5k9w]], [[6b8z]] - hPTP1B catalytic domain + inhibitor<br /> | + | **[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]], [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]], [[4y14]], [[6bmr]], [[6bmv]], [[6bmx]], [[6bmu]], [[6bmw]], [[6bmy]], [[5t19]], [[5k9w]], [[6b8z]], [[5t19]], [[5k9w]] - hPTP1B catalytic domain + inhibitor<br /> |
| - | **[[5kad]], [[5kac]], [[5kab]], [[5ka9]], [[5ka7]], [[5ka3]], [[6b95]], [[1nwl]], [[1nwe]], [[2fjm]], [[6bn5]] | + | **[[5kad]], [[5kac]], [[5kab]], [[5ka9]], [[5ka7]], [[5ka3]], [[6b95]], [[1nwl]], [[1nwe]], [[2fjm]], [[6bn5]], [[5kad]], [[5kac]], [[5kab]], [[5ka9]], [[5ka7]], [[5ka3]], [[5qgf]], [[5qge]], [[5qgd]], [[5qgc]], [[5qgb]], [[5qga]], [[5qg9]], [[5qg8]], [[5qg7]], [[5qg6]], [[5qg5]], [[5qg4]], [[5qg3]], [[5qg2]], [[5qg1]], [[5qg0]], [[5qfz]], [[5qfx]], [[5qfw]], [[5qfv]], [[5qfu]], [[5qft]], [[5qfs]], [[5qfr]], [[5qfq]], [[5qfp]], [[5qfo]], [[5qfn]], [[5qfm]], [[5qfl]], [[5qfk]], [[5qfj]], [[5qfi]], [[5qfh]], [[5qfg]], [[5qff]], [[5qfe]], [[5qfd]], [[5qfc]], [[5qfb]], [[5qfa]], [[5qf9]], [[5qf8]], [[5qf7]], [[5qf6]], [[5qf5]], [[5qf4]], [[5qf3]], [[5qf2]], [[5qf1]], [[5qf0]], [[5qez]], [[5qex]], [[5qew]], [[5qev]], [[5qeu]], [[5qet]], [[5qes]], [[5qer]], [[5qeq]], [[5qep]], [[5qeo]], [[5qen]], [[5qem]], [[5qel]], [[5qek]], [[5qej]], [[5qei]], [[5qeh]], [[5qeg]], [[5qef]], [[5qee]], [[5qed]], [[5qec]], [[5qeb]], [[5qea]], [[5qe9]], [[5qe8]], [[5qe7]], [[5qe6]], [[5qe5]], [[5qe4]], [[5qe3]], [[5qe2]], [[5qe1]], [[5qe0]], [[5qdz]], [[5qdx]], [[5qdw]], [[5qdv]], [[5qdu]], [[5qdt]], [[5qds]], [[5qdr]], [[5qdq]], [[5qdp]], [[5qdo]], [[5qdn]], [[5qdm]], [[5qdl]], [[5qdk]], [[5qdj]], [[5qdi]], [[5qdh]], [[5qdg]], [[5qdf]] - hPTPN1B (mutant) + inhibitor<br /> |
**[[4bjo]] – hPTP1 catalytic domain + NO3<br /> | **[[4bjo]] – hPTP1 catalytic domain + NO3<br /> | ||
| + | **[[6pm8]] – hPTPN1b (mutant) + VO4<br /> | ||
**[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br /> | **[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br /> | ||
**[[6h8r]] – hPTPN5 + inhibitor<br /> | **[[6h8r]] – hPTPN5 + inhibitor<br /> | ||
| - | **[[2cjz]] - hPTPN5 catalytic domain (mutant) + phosphotyrosine<br /> | + | **[[2cjz]] - hPTPN5 catalytic domain (mutant) 258-563 + phosphotyrosine<br /> |
| + | **[[5ow1]], [[5ovx]], [[5ovr]] – hPTP5 catalytic domain + inhibitor<br /> | ||
**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br /> | **[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br /> | ||
**[[3o5x]], [[4pvg]], [[5ehp]], [[5ehr]], [[4rdd]] – hPTPN11 catalytic domain + inhibitor<br /> | **[[3o5x]], [[4pvg]], [[5ehp]], [[5ehr]], [[4rdd]] – hPTPN11 catalytic domain + inhibitor<br /> | ||
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**[[5h08]] – hPTP ζ D1 domain + inhibitor<br /> | **[[5h08]] – hPTP ζ D1 domain + inhibitor<br /> | ||
**[[5bx1]] – hPTP PRL-1 + inhibitor<br /> | **[[5bx1]] – hPTP PRL-1 + inhibitor<br /> | ||
| - | **[[ | + | **[[6md7]], [[6md9]], [[6mda]], [[6mdb]], [[6mdc]], [[6mdd]], [[5xzr]] - hPTP SHP-2 + inhibitor<br /> |
| + | **[[6crg]], [[6cms]], [[6cmr]] - hPTP SHP-2 (mutant) + inhibitor<br /> | ||
**[[1dg9]] – bPTP + HEPES<br /> | **[[1dg9]] – bPTP + HEPES<br /> | ||
| + | **[[1zcl]] - rPTP 4A1 (mutant) + sulfate<br /> | ||
**[[1d2a]] – yPTP + adenine <br /> | **[[1d2a]] – yPTP + adenine <br /> | ||
**[[1d1q]] – yPTP (mutant) + PNPP<br /> | **[[1d1q]] – yPTP (mutant) + PNPP<br /> | ||
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**[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br /> | **[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br /> | ||
**[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br /> | **[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br /> | ||
| + | **[[6iwd]] – hPTPN14 886-1187 + HPV18 CR3 domain<br /> | ||
**[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br /> | **[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br /> | ||
**[[5k22]] – hPTP PRL-2 (mutant) + CNNM3<br /> | **[[5k22]] – hPTP PRL-2 (mutant) + CNNM3<br /> | ||
**[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br /> | **[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br /> | ||
| - | **[[ | + | **[[6nmv]], [[6nmu]], [[6nmt]], [[6nms]], [[6nmr]], [[6bit]] - hPTP SHPS-1 + antibody<br /> |
| - | + | ||
**[[5lxq]] – mPTP + CNNM2<br /> | **[[5lxq]] – mPTP + CNNM2<br /> | ||
**[[5mmz]] – mPTP 4A1 + CNNM2<br /> | **[[5mmz]] – mPTP 4A1 + CNNM2<br /> | ||
**[[4zj7]] – yPTPN CDC14 C terminal + importin<br /> | **[[4zj7]] – yPTPN CDC14 C terminal + importin<br /> | ||
| + | **[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br /> | ||
| + | **[[1jyo]] – StPTP + secretion chaperone SICP<br /> | ||
*'''Yersinia tyrosine phosphatase Yop''' | *'''Yersinia tyrosine phosphatase Yop''' | ||
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**[[3qcn]] - hRPTP-γ domain 1 (mutant) <br /> | **[[3qcn]] - hRPTP-γ domain 1 (mutant) <br /> | ||
**[[2nlk]] - hRPTP-γ catalytic domain<br /> | **[[2nlk]] - hRPTP-γ catalytic domain<br /> | ||
| - | **[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br /> | ||
**[[3jxh]] - hRPTP-γ CA-like domain<br /> | **[[3jxh]] - hRPTP-γ CA-like domain<br /> | ||
**[[5fmv]] - hRPTP-γ domain D1-D4<br /> | **[[5fmv]] - hRPTP-γ domain D1-D4<br /> | ||
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**[[5fn7]] - hRPTP-γ domain D1-D2<br /> | **[[5fn7]] - hRPTP-γ domain D1-D2<br /> | ||
**[[5fn8]] - rRPTP-γ domain D3-D4<br /> | **[[5fn8]] - rRPTP-γ domain D3-D4<br /> | ||
| - | + | **[[4yfe]] - hRPTP-δ FN1-FN2 domain 321-511<br /> | |
| - | **[[4yfe]] - hRPTP-δ FN1-FN2 domain<br /> | + | **[[4yfg]] - hRPTP-δ Ig1-FN1 domain 21-501<br /> |
| - | **[[4yfg]] - hRPTP-δ Ig1-FN1 domain<br /> | + | **[[2dlh]], [[1x5z]] - hRPTP-δ FN3 domain 405-514 – NMR<BR /> |
| - | **[[2dlh]] - hRPTP-δ FN3 domain – NMR<BR /> | + | **[[2yd6]], [[2yd7]] - hRPTP-δ Ig1-2 domain 21-220<br /> |
| - | **[[2yd6]], [[2yd7]] - hRPTP-δ Ig1-2 domain<br /> | + | |
**[[2jjd]] - hRPTP-ε residues 107-697<br /> | **[[2jjd]] - hRPTP-ε residues 107-697<br /> | ||
| + | **[[6d4d]] - hRPTP-ε domain D1 residues 22-313<br /> | ||
| + | **[[6d4f]], [[6d3f]] - hRPTP-ε domain D2 residues 425-700<br /> | ||
| + | **[[2c7s]] - hRPTP-κ residues 865-1154<br /> | ||
**[[2c7s]] - hRPTP-κ residues 865-1154<br /> | **[[2c7s]] - hRPTP-κ residues 865-1154<br /> | ||
**[[1rpm]] - hRPTP-μ catalytic domain<br /> | **[[1rpm]] - hRPTP-μ catalytic domain<br /> | ||
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**[[5awx]] - hRPTP-ζ D1 domain<br /> | **[[5awx]] - hRPTP-ζ D1 domain<br /> | ||
**[[2qt7]], [[3n01]], [[3n4w]], [[3ng8]], [[3np5]] – hRPTP IA-2<br /> | **[[2qt7]], [[3n01]], [[3n4w]], [[3ng8]], [[3np5]] – hRPTP IA-2<br /> | ||
| - | **[[4n5u]] - hRPTP-F | + | **[[4n5u]] - hRPTP-F FN3 domain<br /> |
| - | **[[2edx]] - hRPTP-F | + | **[[2edx]] - hRPTP-F FN3 domain – NMR<BR /> |
| + | **[[6j6u]] - rRPTP-ζ D1-D2 domain<br /> | ||
| + | **[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br /> | ||
*Receptor type tyrosine phosphatase complexes | *Receptor type tyrosine phosphatase complexes | ||
| - | **[[3s3f]] - DmRPTP-10D catalytic domain + VO4<BR /> | ||
| - | **[[3s3h]] - DmRPTP-10D catalytic domain + peptide<br /> | ||
| - | **[[3s3k]] - DmRPTP-10D catalytic domain + inhibitor<br /> | ||
**[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br /> | **[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br /> | ||
**[[2h03]] - hRPTP-β catalytic domain (mutant) + inhibitor<br /> | **[[2h03]] - hRPTP-β catalytic domain (mutant) + inhibitor<br /> | ||
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**[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br /> | **[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br /> | ||
**[[5e5r]] - hRPTP-γ domain CA + contactin 3<br /> | **[[5e5r]] - hRPTP-γ domain CA + contactin 3<br /> | ||
| - | **[[ | + | **[[4rca]], [[4y61]] - hRPTP-δ Ig1-Ig2 domain 21-318 + SLITRK1<br /> |
| - | **[[ | + | **[[5xnp]] - hRPTP-δ Ig1-Ig2 domain (mutant) + SALM5<br /> |
| - | **[[ | + | **[[6kip]] - hRPTP-δ residues 1617-1912 + liprin<br /> |
| - | **[[5y32]], [[4yfd]], [[4yh7]], [[5wy8]] - hRPTP-δ + IL1RAPL1<br /> | + | **[[5y32]], [[4yfd]], [[4yh7]], [[5wy8]] - hRPTP-δ Ig1-Ig2 domain + IL1RAPL1<br /> |
| + | **[[5xnp]] - hRPTP-d Ig1-Ig2 domain (mutant) + SALM5<br /> | ||
| + | **[[6kip]] - hRPTP-d residues 1617-1912 + liprin<br /> | ||
**[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br /> | **[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br /> | ||
**[[3s97]] - hRPTP-ζ CA-like domain + congtactin Ig domains<br /> | **[[3s97]] - hRPTP-ζ CA-like domain + congtactin Ig domains<br /> | ||
| + | **[[5h08]] – hPTP ζ D1 domain 1698-1993 + inhibitor<br /> | ||
| + | **[[6kr4]] - hRPTP-F residues 1332-1907 + liprin<br /> | ||
**[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br /> | **[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br /> | ||
| + | **[[5e5u]] - mRPTP-γ domain CA + contactin 6<br /> | ||
| + | **[[3kld]] - mRPTP-γ CA-like domain + contactin 4<br /> | ||
| + | **[[5xwu]] - mRPTP- Ig1-Ig3 domain + LRR-IG<br /> | ||
| + | **[[5xwt]] - mRPTP- Ig1-FN1 domain + LRR-IG<br /> | ||
| + | **[[3s3f]] - DmRPTP-10D catalytic domain + VO4<BR /> | ||
| + | **[[3s3h]] - DmRPTP-10D catalytic domain + peptide<br /> | ||
| + | **[[3s3k]] - DmRPTP-10D catalytic domain + inhibitor<br /> | ||
*'''Dual-specificity tyrosine phosphatase or Dual-specificity protein phosphatase''' See [[MAP kinase phosphatase]]. | *'''Dual-specificity tyrosine phosphatase or Dual-specificity protein phosphatase''' See [[MAP kinase phosphatase]]. | ||
| Line 236: | Line 268: | ||
*'''Low molecular weight tyrosine phosphatase (LMW-PTP)''' | *'''Low molecular weight tyrosine phosphatase (LMW-PTP)''' | ||
| + | **[[1xww]], [[4z99]], [[5pnt]] - hLMW-PTP <br /> | ||
| + | **[[1phr]] - bLMW-PTP<br /> | ||
**[[1p8a]] – LMW-PTP (mutant) – ''Tritrichomonas foetus'' – NMR<BR /> | **[[1p8a]] – LMW-PTP (mutant) – ''Tritrichomonas foetus'' – NMR<BR /> | ||
**[[2cwd]] – LMW-PTP – ''Thermus thermophilus''<br /> | **[[2cwd]] – LMW-PTP – ''Thermus thermophilus''<br /> | ||
**[[5got]] – LMW-PTP – ''Streptococcus pyogenes''<br /> | **[[5got]] – LMW-PTP – ''Streptococcus pyogenes''<br /> | ||
**[[5z3m]] – LMW-PTP – ''Vibrio cholerae''<br /> | **[[5z3m]] – LMW-PTP – ''Vibrio cholerae''<br /> | ||
| - | **[[1phr]] - bLMW-PTP<br /> | ||
| - | **[[1xww]], [[4z99]], [[5pnt]] - hLMW-PTP <br /> | ||
**[[1u2p]], [[2luo]] – MtLMW-PTP – ''Mycobacterium tuberculosis''<br /> | **[[1u2p]], [[2luo]] – MtLMW-PTP – ''Mycobacterium tuberculosis''<br /> | ||
**[[2oz5]] – MtLMW-PTP + inhibitor<br /> | **[[2oz5]] – MtLMW-PTP + inhibitor<br /> | ||
Revision as of 09:14, 17 March 2020
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3D Structures of tyrosine phosphatase
Updated on 17-March-2020
2shp, 6ihz, 6crf, 6cmp - hPTP SHP-2 (mutant)**1c0e – bPTP (mutant) – bovine
References
- ↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
- ↑ Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, Cirri P. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016 Oct;1864(10):1339-55. doi:, 10.1016/j.bbapap.2016.07.001. Epub 2016 Jul 13. PMID:27421795 doi:http://dx.doi.org/10.1016/j.bbapap.2016.07.001
- ↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837
