2qlv

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[[Image:2qlv.jpg|left|200px]]
[[Image:2qlv.jpg|left|200px]]
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{{Structure
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|PDB= 2qlv |SIZE=350|CAPTION= <scene name='initialview01'>2qlv</scene>, resolution 2.600&Aring;
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The line below this paragraph, containing "STRUCTURE_2qlv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= SNF1, CAT1, CCR1, GLC2, PAS14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SIP2, SPM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SNF4, CAT3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_2qlv| PDB=2qlv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qlv OCA], [http://www.ebi.ac.uk/pdbsum/2qlv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qlv RCSB]</span>
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'''Crystal structure of the heterotrimer core of the S. cerevisiae AMPK homolog SNF1'''
'''Crystal structure of the heterotrimer core of the S. cerevisiae AMPK homolog SNF1'''
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[[Category: Rudolph, M J.]]
[[Category: Rudolph, M J.]]
[[Category: Tong, L.]]
[[Category: Tong, L.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: carbohydrate metabolism]]
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[[Category: Carbohydrate metabolism]]
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[[Category: cbs domain]]
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[[Category: Cbs domain]]
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[[Category: heterotrimer]]
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[[Category: Heterotrimer]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: myristate]]
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[[Category: Myristate]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: transferase/protein binding complex]]
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[[Category: Transferase/protein binding complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:10:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:50:40 2008''
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Revision as of 12:10, 4 May 2008

Image:2qlv.jpg

Template:STRUCTURE 2qlv

Crystal structure of the heterotrimer core of the S. cerevisiae AMPK homolog SNF1


Overview

AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis in mammals and is an attractive target for drug discovery against diabetes, obesity and other diseases. The AMPK homologue in Saccharomyces cerevisiae, known as SNF1, is essential for responses to glucose starvation as well as for other cellular processes, although SNF1 seems to be activated by a ligand other than AMP. Here we report the crystal structure at 2.6 A resolution of the heterotrimer core of SNF1. The ligand-binding site in the gamma-subunit (Snf4) has clear structural differences from that of the Schizosaccharomyces pombe enzyme, although our crystallographic data indicate that AMP can also bind to Snf4. The glycogen-binding domain in the beta-subunit (Sip2) interacts with Snf4 in the heterotrimer but should still be able to bind carbohydrates. Our structure is supported by a large body of biochemical and genetic data on this complex. Most significantly, the structure reveals that part of the regulatory sequence in the alpha-subunit (Snf1) is sequestered by Snf4, demonstrating a direct interaction between the alpha- and gamma-subunits and indicating that our structure may represent the heterotrimer core of SNF1 in its activated state.

About this Structure

2QLV is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1., Amodeo GA, Rudolph MJ, Tong L, Nature. 2007 Sep 27;449(7161):492-5. Epub 2007 Sep 12. PMID:17851534 Page seeded by OCA on Sun May 4 15:10:36 2008

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