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2x0y

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==Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds==
==Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds==
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<StructureSection load='2x0y' size='340' side='right' caption='[[2x0y]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='2x0y' size='340' side='right'caption='[[2x0y]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x0y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X0Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x0y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X0Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=X0T:7-[(2S)-2,3-DIHYDROXYPROPYL]-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE'>X0T</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X0T:7-[(2S)-2,3-DIHYDROXYPROPYL]-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE'>X0T</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j62|2j62]], [[2cbi|2cbi]], [[2jh2|2jh2]], [[2wb5|2wb5]], [[2v5c|2v5c]], [[2cbj|2cbj]], [[2vur|2vur]], [[2v5d|2v5d]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j62|2j62]], [[2cbi|2cbi]], [[2jh2|2jh2]], [[2wb5|2wb5]], [[2v5c|2v5c]], [[2cbj|2cbj]], [[2vur|2vur]], [[2v5d|2v5d]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0y OCA], [http://pdbe.org/2x0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x0y RCSB], [http://www.ebi.ac.uk/pdbsum/2x0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0y OCA], [http://pdbe.org/2x0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x0y RCSB], [http://www.ebi.ac.uk/pdbsum/2x0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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==See Also==
==See Also==
*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
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*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Beta-N-acetylhexosaminidase]]
[[Category: Beta-N-acetylhexosaminidase]]
[[Category: Clostridium perfringens]]
[[Category: Clostridium perfringens]]
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[[Category: Large Structures]]
[[Category: Aalten, D M.F van]]
[[Category: Aalten, D M.F van]]
[[Category: Dorfmueller, H C]]
[[Category: Dorfmueller, H C]]

Revision as of 15:02, 8 July 2020

Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds

PDB ID 2x0y

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