2qrn

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[[Image:2qrn.jpg|left|200px]]
[[Image:2qrn.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qrn |SIZE=350|CAPTION= <scene name='initialview01'>2qrn</scene>, resolution 3.40&Aring;
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The line below this paragraph, containing "STRUCTURE_2qrn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DCM:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DCM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UDP:URIDINE-5&#39;-DIPHOSPHATE'>UDP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= DCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2qrn| PDB=2qrn | SCENE= }}
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|RELATEDENTRY=[[2qro|2QRO]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qrn OCA], [http://www.ebi.ac.uk/pdbsum/2qrn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qrn RCSB]</span>
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}}
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'''Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex'''
'''Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex'''
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[[Category: Ealick, S E.]]
[[Category: Ealick, S E.]]
[[Category: Soriano, E V.]]
[[Category: Soriano, E V.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: deoxycytidine kinase]]
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[[Category: Deoxycytidine kinase]]
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[[Category: deoxycytidine monophosphate]]
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[[Category: Deoxycytidine monophosphate]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: uridine diphosphate]]
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[[Category: Uridine diphosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:32:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:52:34 2008''
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Revision as of 12:32, 4 May 2008

Image:2qrn.jpg

Template:STRUCTURE 2qrn

Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex


Overview

Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg2+ ion, and with dAMP, UDP and Mg2+ ion are reported. Structural comparisons show that the product complexes with UDP and a dead-end complex with substrate and UDP have similar active-site conformations.

About this Structure

2QRN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of human deoxycytidine kinase product complexes., Soriano EV, Clark VC, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1201-7. Epub 2007, Nov 16. PMID:18084067 Page seeded by OCA on Sun May 4 15:32:29 2008

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OCA

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