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UDP-galactose 4-epimerase

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== Structural highlights ==
== Structural highlights ==
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GalE active site contains the <scene name='57/572287/Cv/4'>substrate UDP-galactose</scene> (UDP-gal) and the <scene name='57/572287/Cv/6'>cofactor NAD</scene>. Water molecules shown as red spheres. <scene name='57/572287/Cv/8'>Tyrosine residue is the catalytic base</scene> which produces the ketose intermediate<ref>PMID:16946458</ref>.
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GalE active site contains the <scene name='57/572287/Cv/9'>substrate UDP-galactose</scene> (UDP-gal) and the <scene name='57/572287/Cv/10'>cofactor NAD</scene>. Water molecules are shown as red spheres. <scene name='57/572287/Cv/11'>Tyrosine residue is the catalytic base</scene> which produces the ketose intermediate<ref>PMID:16946458</ref>.
</StructureSection>
</StructureSection>

Revision as of 12:21, 7 October 2019

Structure of UDP-galactose 4 epimerase complex with NAD and UDP-galactose (PDB entry 2cnb)

Drag the structure with the mouse to rotate

3D structures of UDP-galactose 4 epimerase

Updated on 07-October-2019

References

  1. ↑ Mozzi F, Savoy de Giori G, Font de Valdez G. UDP-galactose 4-epimerase: a key enzyme in exopolysaccharide formation by Lactobacillus casei CRL 87 in controlled pH batch cultures. J Appl Microbiol. 2003;94(2):175-83. PMID:12534808
  2. ↑ Park HD, Park KU, Kim JQ, Shin CH, Yang SW, Lee DH, Song YH, Song J. The molecular basis of UDP-galactose-4-epimerase (GALE) deficiency galactosemia in Korean patients. Genet Med. 2005 Nov-Dec;7(9):646-9. PMID:16301867 doi:10.109701.gim.0000194023.27802.2d
  3. ↑ Alphey MS, Burton A, Urbaniak MD, Boons GJ, Ferguson MA, Hunter WN. Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt, 9):829-34. Epub 2006 Aug 11. PMID:16946458 doi:10.1107/S1744309106028740

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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