Uridine 5'-monophosphate synthase
From Proteopedia
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**[[2v30]], [[2qcd]], [[2qcn]] - hOPD + UMP<br /> | **[[2v30]], [[2qcd]], [[2qcn]] - hOPD + UMP<br /> | ||
**[[3ewy]] - hOPD (mutant) + UMP<br /> | **[[3ewy]] - hOPD (mutant) + UMP<br /> | ||
| - | **[[2qcg]], [[2qch | + | **[[2qcg]], [[2qch]], [[3bgj]], [[3bk0]], [[3g3d]], [[3g3m]], [[3ewz]], [[3ex2]], [[3ex3]],[[3dbp]], [[3l0k]], [[3l0n]], [[3mo7]], [[3mw7]] - hOPD + UMP derivative<br /> |
**[[2qcf]], [[2qcm]], [[2qcn]], [[3ewu]], [[3ewx]], [[3ex6]] - hOPD (mutant) + UMP derivative<br /> | **[[2qcf]], [[2qcm]], [[2qcn]], [[3ewu]], [[3ewx]], [[3ex6]] - hOPD (mutant) + UMP derivative<br /> | ||
**[[2qcl]] - hOPD (mutant) + OMP<br /> | **[[2qcl]] - hOPD (mutant) + OMP<br /> | ||
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**[[3gdl]] - yOPD + UMP derivative<br /> | **[[3gdl]] - yOPD + UMP derivative<br /> | ||
**[[1dqx]], [[3gdt]] - yOPD (mutant) + UMP derivative<br /> | **[[1dqx]], [[3gdt]] - yOPD (mutant) + UMP derivative<br /> | ||
| - | **[[4o8r]], [[4o11]], [[4nx5]], [[4nt0]], [[4nuw]], [[3wjw]], [[3wjx]], [[3wjy]], [[3wjz]], [[3w07]], [[3sgu]], [[3ssj]], [[3sw6]], [[3thq]], [[3wjw]], [[3wjx], [[3w07]]] - MtOPD + UMP derivative<br /> | + | **[[4o8r]], [[4o11]], [[4nx5]], [[4nt0]], [[4nuw]], [[3wjw]], [[3wjx]], [[3wjy]], [[3wjz]], [[3w07]], [[3sgu]], [[3ssj]], [[3sw6]], [[3thq]], [[3wjw]], [[3wjx]], [[3w07]]] - MtOPD + UMP derivative<br /> |
**[[1km1]], [[1km2]], [[1km3]], [[1km4]], [[1km5]], [[1kly]], [[1klz]], [[1km0]], [[1los]], [[2zz2]], [[2zz3]], [[2zz4]], [[2zz5]], [[2zz6]], [[2zz7]], [[3g1a]], [[3g1d]], [[3g1v]], [[3g1x]], [[3g22]], [[3g24]], [[3lld]], [[3llf]], [[3nq6]], [[3pbu]], [[3pbv]], [[3pbw]], [[3pby]], [[3pc0]], [[3sy5]], [[3wjy]], [[3wjz]], [[2e6y]] - MtOPD (mutant) + UMP derivative<br /> | **[[1km1]], [[1km2]], [[1km3]], [[1km4]], [[1km5]], [[1kly]], [[1klz]], [[1km0]], [[1los]], [[2zz2]], [[2zz3]], [[2zz4]], [[2zz5]], [[2zz6]], [[2zz7]], [[3g1a]], [[3g1d]], [[3g1v]], [[3g1x]], [[3g22]], [[3g24]], [[3lld]], [[3llf]], [[3nq6]], [[3pbu]], [[3pbv]], [[3pbw]], [[3pby]], [[3pc0]], [[3sy5]], [[3wjy]], [[3wjz]], [[2e6y]] - MtOPD (mutant) + UMP derivative<br /> | ||
**[[3wk0]], [[3wk1]], [[3wk2]], [[3wk3]] - MtOPD + OMP derivative<br /> | **[[3wk0]], [[3wk1]], [[3wk2]], [[3wk3]] - MtOPD + OMP derivative<br /> | ||
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**[[3mi2]], [[4hib]], [[4hkp]] - hOPD + inhibitor<br /> | **[[3mi2]], [[4hib]], [[4hkp]] - hOPD + inhibitor<br /> | ||
**[[3bvj]] - hOPD + XMP<br /> | **[[3bvj]] - hOPD + XMP<br /> | ||
| + | **[[3bgg]], [[3ex4]] - hOPD + BMP<br /> | ||
**[[4lw7]], [[3ltp]], [[4luj]], [[1lor]] – MtOPD + BMP <br /> | **[[4lw7]], [[3ltp]], [[4luj]], [[1lor]] – MtOPD + BMP <br /> | ||
**[[4lc6]], [[4lc8]], [[4fx8]], [[4gc4]], [[4fx6]], [[4fxr]], [[3v1p]], [[1x1z]], [[3lht]], [[3lhu]], [[3lhv]], [[3lhw]], [[3lhy]], [[3lhz]], [[3li0]], [[3li1]], [[3lts]], [[3lty]], [[3lv5]], [[3lv6]], [[3m1z]], [[3nq7]], [[3nqa]], [[3nqc]], [[3nqd]], [[3nqe]], [[3nqf]], [[3nqg]], [[3nqm]], [[3p5y]], [[3p5z]], [[3p60]], [[3p61]], [[3qez]], [[3qf0]], [[3qmr]], [[3qms]], [[3qmt]], [[3rlu]], [[3rlv]], [[3siz]], [[3sj3]], [[3v1p]], [[4lw7]], [[2zz1]] – MtOPD (mutant) + BMP <br /> | **[[4lc6]], [[4lc8]], [[4fx8]], [[4gc4]], [[4fx6]], [[4fxr]], [[3v1p]], [[1x1z]], [[3lht]], [[3lhu]], [[3lhv]], [[3lhw]], [[3lhy]], [[3lhz]], [[3li0]], [[3li1]], [[3lts]], [[3lty]], [[3lv5]], [[3lv6]], [[3m1z]], [[3nq7]], [[3nqa]], [[3nqc]], [[3nqd]], [[3nqe]], [[3nqf]], [[3nqg]], [[3nqm]], [[3p5y]], [[3p5z]], [[3p60]], [[3p61]], [[3qez]], [[3qf0]], [[3qmr]], [[3qms]], [[3qmt]], [[3rlu]], [[3rlv]], [[3siz]], [[3sj3]], [[3v1p]], [[4lw7]], [[2zz1]] – MtOPD (mutant) + BMP <br /> | ||
Revision as of 17:46, 5 October 2018
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3D structures of uridine 5'-monophosphate synthase
Updated on 05-October-2018
References
- ↑ Yablonski MJ, Pasek DA, Han BD, Jones ME, Traut TW. Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase. J Biol Chem. 1996 May 3;271(18):10704-8. PMID:8631878
- ↑ Grohmann K, Lauffer H, Lauenstein P, Hoffmann GF, Seidlitz G. Hereditary orotic aciduria with epilepsy and without megaloblastic anemia. Neuropediatrics. 2015 Apr;46(2):123-5. doi: 10.1055/s-0035-1547341. Epub 2015 Mar, 10. PMID:25757096 doi:http://dx.doi.org/10.1055/s-0035-1547341
- ↑ Schwenger B, Schober S, Simon D. DUMPS cattle carry a point mutation in the uridine monophosphate synthase gene. Genomics. 1993 Apr;16(1):241-4. PMID:8486364 doi:http://dx.doi.org/10.1006/geno.1993.1165
- ↑ Wittmann JG, Heinrich D, Gasow K, Frey A, Diederichsen U, Rudolph MG. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure. 2008 Jan;16(1):82-92. PMID:18184586 doi:http://dx.doi.org/10.1016/j.str.2007.10.020
