2qt7

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[[Image:2qt7.jpg|left|200px]]
[[Image:2qt7.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qt7 |SIZE=350|CAPTION= <scene name='initialview01'>2qt7</scene>, resolution 1.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2qt7", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Residue+A+202'>AC1</scene>, <scene name='pdbsite=AC2:Ca+Binding+Site+For+Residue+A+203'>AC2</scene> and <scene name='pdbsite=AC3:Ca+Binding+Site+For+Residue+B+201'>AC3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PTPRN, ICA3, ICA512 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2qt7| PDB=2qt7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qt7 OCA], [http://www.ebi.ac.uk/pdbsum/2qt7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qt7 RCSB]</span>
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}}
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'''Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms'''
'''Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms'''
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[[Category: Primo, M E.]]
[[Category: Primo, M E.]]
[[Category: Sica, M P.]]
[[Category: Sica, M P.]]
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[[Category: autoimmunity]]
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[[Category: Autoimmunity]]
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[[Category: diabetes]]
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[[Category: Diabetes]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: ia-2]]
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[[Category: Ia-2]]
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[[Category: ica-512]]
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[[Category: Ica-512]]
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[[Category: protein-tyrosine phosphatase]]
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[[Category: Protein-tyrosine phosphatase]]
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[[Category: proteolysis]]
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[[Category: Proteolysis]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: transmembrane protein]]
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[[Category: Transmembrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:38:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:53:02 2008''
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Revision as of 12:38, 4 May 2008

Image:2qt7.jpg

Template:STRUCTURE 2qt7

Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms


Overview

IA-2 (insulinoma-associated protein 2) is a protein-tyrosine phosphatase receptor located in secretory granules of neuroendocrine cells. Initially, it attracted attention due to its involvement in the autoimmune response associated to diabetes. Later it was found that upon exocytosis, the cytoplasmic domain of IA-2 is cleaved and relocated to the nucleus, where it enhances the transcription of the insulin gene. A concerted functioning of the whole receptor is to be expected. However, very little is known about the structure and function of the transmembrane and extracellular domains of IA-2. To address this issue, we solved the x-ray structure of the mature ectodomain of IA-2 (meIA-2) to 1.30A resolution. The fold of meIA-2 is related to the SEA (sea urchin sperm protein, enterokinase, agrin)) domains of mucins, suggesting its participation in adhesive contacts to the extracellular matrix and providing clues on how this kind of molecule may associate and form homo- and heterodimers. Moreover, we discovered that meIA-2 is self-proteolyzed in vitro by reactive oxygen species, suggesting the possibility of a new shedding mechanism that might be significant in normal function or pathological processes. Knowledge of meIA-2 structure should facilitate the search of its possible ligands and molecular interactions.

About this Structure

2QT7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the Mature Ectodomain of the Human Receptor-type Protein-tyrosine Phosphatase IA-2., Primo ME, Klinke S, Sica MP, Goldbaum FA, Jakoncic J, Poskus E, Ermacora MR, J Biol Chem. 2008 Feb 22;283(8):4674-81. Epub 2007 Nov 29. PMID:18048354 Page seeded by OCA on Sun May 4 15:38:16 2008

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