2qtw

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[[Image:2qtw.jpg|left|200px]]
[[Image:2qtw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qtw |SIZE=350|CAPTION= <scene name='initialview01'>2qtw</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2qtw", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+B+1001'>AC1</scene> and <scene name='pdbsite=AC2:Ca+Binding+Site+For+Residue+B+1'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= PCSK9, NARC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2qtw| PDB=2qtw | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qtw OCA], [http://www.ebi.ac.uk/pdbsum/2qtw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qtw RCSB]</span>
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}}
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'''The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain'''
'''The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain'''
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[[Category: Li, J.]]
[[Category: Li, J.]]
[[Category: Spraggon, G.]]
[[Category: Spraggon, G.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: autocatalytic cleavage]]
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[[Category: Autocatalytic cleavage]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: cholesterol metabolism]]
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[[Category: Cholesterol metabolism]]
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[[Category: coronary heart disease]]
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[[Category: Coronary heart disease]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: hypercholesterolemia]]
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[[Category: Hypercholesterolemia]]
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[[Category: lipid metabolism]]
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[[Category: Lipid metabolism]]
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[[Category: low density lipoprotein receptor]]
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[[Category: Low density lipoprotein receptor]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: pro-protein convertase]]
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[[Category: Pro-protein convertase]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: secreted]]
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[[Category: Secreted]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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[[Category: steroid metabolism]]
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[[Category: Steroid metabolism]]
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[[Category: zymogen]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:40:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:53:15 2008''
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Revision as of 12:40, 4 May 2008

Image:2qtw.jpg

Template:STRUCTURE 2qtw

The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain


Overview

Mutations in proprotein convertase subtilisin/kexin type 9 (PCSK9) are strongly associated with levels of low-density lipoprotein cholesterol in the blood plasma and, thereby, occurrence or resistance to atherosclerosis and coronary heart disease. Despite this importance, relatively little is known about the biology of PCSK9. Here, the crystal structure of a full-length construct of PCSK9 solved to 1.9-A resolution is presented. The structure contains a fully folded C-terminal cysteine-rich domain (CRD), showing a distinct structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. This structural relationship between the CRD of PCSK9 and the resistin family is not observed in primary sequence comparisons and strongly suggests a distant evolutionary link between the two molecules. This three-dimensional homology provides insight into the function of PCSK9 at the molecular level and will help to dissect the link between PCSK9 and CHD.

About this Structure

2QTW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain., Hampton EN, Knuth MW, Li J, Harris JL, Lesley SA, Spraggon G, Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14604-9. Epub 2007 Sep 5. PMID:17804797 Page seeded by OCA on Sun May 4 15:40:28 2008

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