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6afr
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol== | |
| - | + | <StructureSection load='6afr' size='340' side='right' caption='[[6afr]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6afr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AFR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9E3:5-[(4-fluoranylimidazol-1-yl)methyl]quinolin-8-ol'>9E3</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6afr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6afr OCA], [http://pdbe.org/6afr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6afr RCSB], [http://www.ebi.ac.uk/pdbsum/6afr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6afr ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Jiang, X R]] | ||
[[Category: Luo, C]] | [[Category: Luo, C]] | ||
| - | [[Category: Jiang, X.R]] | ||
[[Category: Xing, J]] | [[Category: Xing, J]] | ||
| + | [[Category: Zhang, R K]] | ||
| + | [[Category: Zheng, M Y]] | ||
| + | [[Category: Brd4]] | ||
| + | [[Category: Epigenetic]] | ||
| + | [[Category: Signaling protein-inhibitor complex]] | ||
Revision as of 06:42, 12 December 2018
Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol
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