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6hsn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the ternary complex of GephE-ADP-GABA(A) receptor derived peptide== | |
| - | + | <StructureSection load='6hsn' size='340' side='right' caption='[[6hsn]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hsn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HSN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3F8:1,1-[ETHANE-1,2-DIYLBIS(OXYETHANE-2,1-DIYL)]BIS(1H-PYRROLE-2,5-DIONE)'>3F8</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fgc|6fgc]], [[6fgd|6fgd]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hsn OCA], [http://pdbe.org/6hsn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hsn RCSB], [http://www.ebi.ac.uk/pdbsum/6hsn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hsn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref> [[http://www.uniprot.org/uniprot/GBRA3_RAT GBRA3_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kasaragod, V B]] | ||
| + | [[Category: Schindelin, H]] | ||
| + | [[Category: Gabaa receptor]] | ||
| + | [[Category: Gephyrin]] | ||
| + | [[Category: Moonlighting protein]] | ||
| + | [[Category: Scaffolding protein]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 12:09, 16 January 2019
Crystal structure of the ternary complex of GephE-ADP-GABA(A) receptor derived peptide
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