6ht5

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m (Protected "6ht5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6ht5 is ON HOLD until Paper Publication
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==Oct4/Sox2:UTF1 structure==
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<StructureSection load='6ht5' size='340' side='right'caption='[[6ht5]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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Authors: Vahokoski, J., Meusch, D., Groves, M., Pogenberg, V., Wilmanns, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ht5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HT5 FirstGlance]. <br>
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Description: Oct4/Sox2:UTF1 structure
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ht5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ht5 OCA], [http://pdbe.org/6ht5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ht5 RCSB], [http://www.ebi.ac.uk/pdbsum/6ht5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ht5 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Vahokoski, J]]
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== Function ==
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[[http://www.uniprot.org/uniprot/PO5F1_MOUSE PO5F1_MOUSE]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.<ref>PMID:17496161</ref> <ref>PMID:17525163</ref> [[http://www.uniprot.org/uniprot/SOX2_MOUSE SOX2_MOUSE]] Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).<ref>PMID:17097055</ref> <ref>PMID:22198669</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Groves, M]]
[[Category: Groves, M]]
[[Category: Meusch, D]]
[[Category: Meusch, D]]
[[Category: Pogenberg, V]]
[[Category: Pogenberg, V]]
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[[Category: Vahokoski, J]]
[[Category: Wilmanns, M]]
[[Category: Wilmanns, M]]
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[[Category: Cell reprogramming]]
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[[Category: Dna binding]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]

Revision as of 06:45, 23 October 2019

Oct4/Sox2:UTF1 structure

PDB ID 6ht5

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