2r2i

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[[Image:2r2i.jpg|left|200px]]
[[Image:2r2i.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2r2i |SIZE=350|CAPTION= <scene name='initialview01'>2r2i</scene>, resolution 2.000&Aring;
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The line below this paragraph, containing "STRUCTURE_2r2i", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= GUCA1A, GCAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
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-->
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|DOMAIN=
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{{STRUCTURE_2r2i| PDB=2r2i | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [http://www.ebi.ac.uk/pdbsum/2r2i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB]</span>
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}}
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'''Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound'''
'''Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Stephen, R.]]
[[Category: Stephen, R.]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: ef hand]]
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[[Category: Ef hand]]
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[[Category: gcap]]
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[[Category: Gcap]]
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[[Category: gcap-1]]
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[[Category: Gcap-1]]
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[[Category: gcap1]]
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[[Category: Gcap1]]
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[[Category: guanylate cyclase activating protein]]
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[[Category: Guanylate cyclase activating protein]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: lyase activator]]
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[[Category: Lyase activator]]
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[[Category: myristate]]
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[[Category: Myristate]]
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[[Category: sensory transduction]]
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[[Category: Sensory transduction]]
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[[Category: vision]]
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[[Category: Vision]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:07:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:55:50 2008''
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Revision as of 13:07, 4 May 2008

Image:2r2i.jpg

Template:STRUCTURE 2r2i

Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound


Overview

Guanylate cyclase-activating proteins (GCAPs) are Ca(2+)-binding proteins myristoylated at the N terminus that regulate guanylate cyclases in photoreceptor cells and belong to the family of neuronal calcium sensors (NCS). Many NCS proteins display a recoverin-like "calcium-myristoyl switch" whereby the myristoyl group, buried inside the protein in the Ca(2+)-free state, becomes fully exposed upon Ca(2+) binding. Here we present a 2.0 A resolution crystal structure of myristoylated GCAP1 with Ca(2+) bound. The acyl group is buried inside Ca(2+)-bound GCAP1. This is in sharp contrast to Ca(2+)-bound recoverin, where the myristoyl group is solvent exposed. Furthermore, we provide direct evidence that the acyl group in GCAP1 remains buried in the Ca(2+)-free state and does not undergo switching. A pronounced kink in the C-terminal helix and the presence of the myristoyl group allow clustering of sequence elements crucial for GCAP1 activity.

About this Structure

2R2I is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1., Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC, Structure. 2007 Nov;15(11):1392-402. PMID:17997965 Page seeded by OCA on Sun May 4 16:07:31 2008

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