2r4g

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[[Image:2r4g.jpg|left|200px]]
[[Image:2r4g.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2r4g |SIZE=350|CAPTION= <scene name='initialview01'>2r4g</scene>, resolution 1.71&Aring;
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The line below this paragraph, containing "STRUCTURE_2r4g", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 Tetrahymena thermophila])
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-->
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|DOMAIN=
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{{STRUCTURE_2r4g| PDB=2r4g | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4g OCA], [http://www.ebi.ac.uk/pdbsum/2r4g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r4g RCSB]</span>
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}}
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'''The high resolution structure of the RNA-binding domain of telomerase'''
'''The high resolution structure of the RNA-binding domain of telomerase'''
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[[Category: Rouda, S.]]
[[Category: Rouda, S.]]
[[Category: Skordalakes, E.]]
[[Category: Skordalakes, E.]]
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[[Category: chromosomal protein]]
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[[Category: Chromosomal protein]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: nucleotidyltransferase]]
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[[Category: Nucleotidyltransferase]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: rna-directed dna polymerase]]
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[[Category: Rna-directed dna polymerase]]
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[[Category: telomerase]]
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[[Category: Telomerase]]
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[[Category: telomere]]
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[[Category: Telomere]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:13:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:24 2008''
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Revision as of 13:13, 4 May 2008

Image:2r4g.jpg

Template:STRUCTURE 2r4g

The high resolution structure of the RNA-binding domain of telomerase


Overview

Telomerase, a ribonucleoprotein complex, replicates the linear ends of eukaryotic chromosomes, thus taking care of the "end of replication problem." TERT contains an essential and universally conserved domain (TRBD) that makes extensive contacts with the RNA (TER) component of the holoenzyme, and this interaction is thought to facilitate TERT/TER assembly and repeat-addition processivity. Here, we present a high-resolution structure of TRBD from Tetrahymena thermophila. The nearly all-helical structure comprises a nucleic acid-binding fold suitable for TER binding. An extended pocket on the surface of the protein, formed by two conserved motifs (CP and T motifs) comprises TRBD's RNA-binding pocket. The width and the chemical nature of this pocket suggest that it binds both single- and double-stranded RNA, possibly stem I, and the template boundary element (TBE). Moreover, the structure provides clues into the role of this domain in TERT/TER stabilization and telomerase repeat-addition processivity.

About this Structure

2R4G is a Single protein structure of sequence from Tetrahymena thermophila. Full crystallographic information is available from OCA.

Reference

Structure of the RNA-binding domain of telomerase: implications for RNA recognition and binding., Rouda S, Skordalakes E, Structure. 2007 Nov;15(11):1403-12. PMID:17997966 Page seeded by OCA on Sun May 4 16:13:47 2008

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