2xq4

From Proteopedia

(Difference between revisions)

Revision as of 08:02, 4 November 2020

Pentameric ligand gated ion channel GLIC in complex with tetramethylarsonium (TMAs)

Structural highlights

2xq4 is a 5 chain structure with sequence from Glovi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	2xqa, 2xq7, 2xq9, 2xq3, 2xq5, 2xq8, 2xq6
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.^[1]

Publication Abstract from PubMed

The flow of ions through cation-selective members of the pentameric ligand-gated ion channel family is inhibited by a structurally diverse class of molecules that bind to the transmembrane pore in the open state of the protein. To obtain insight into the mechanism of channel block, we have investigated the binding of positively charged inhibitors to the open channel of the bacterial homolog GLIC by using X-ray crystallography and electrophysiology. Our studies reveal the location of two regions for interactions, with larger blockers binding in the center of the membrane and divalent transition metal ions binding to the narrow intracellular pore entry. The results provide a structural foundation for understanding the interactions of the channel with inhibitors that is relevant for the entire family.

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel.,Hilf RJ, Bertozzi C, Zimmermann I, Reiter A, Trauner D, Dutzler R Nat Struct Mol Biol. 2010 Nov;17(11):1330-1336. Epub 2010 Oct 31. PMID:21037567^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371
↑ Hilf RJ, Bertozzi C, Zimmermann I, Reiter A, Trauner D, Dutzler R. Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel. Nat Struct Mol Biol. 2010 Nov;17(11):1330-1336. Epub 2010 Oct 31. PMID:21037567 doi:10.1038/nsmb.1933

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xq4"

@@ Line 1: / Line 1: @@
 ==Pentameric ligand gated ion channel GLIC in complex with tetramethylarsonium (TMAs)==
-<StructureSection load='2xq4' size='340' side='right' caption='[[2xq4]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
+<StructureSection load='2xq4' size='340' side='right'caption='[[2xq4]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xq4]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQ4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xq4]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XQ4 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xqa|2xqa]], [[2xq7|2xq7]], [[2xq9|2xq9]], [[2xq3|2xq3]], [[2xq5|2xq5]], [[2xq8|2xq8]], [[2xq6|2xq6]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq4 OCA], [http://pdbe.org/2xq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq4 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq4 OCA], [http://pdbe.org/2xq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq4 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 21: @@
 ==See Also==
-*[[Ion channels|Ion channels]]
+*[[Ion channels 3D structures|Ion channels 3D structures]]
 == References ==
 <references/>
@@ Line 27: / Line 27: @@
 </StructureSection>
 [[Category: Glovi]]
+[[Category: Large Structures]]
 [[Category: Bertozzi, C]]
 [[Category: Dutzler, R]]

2xq4

From Proteopedia

Revision as of 08:02, 4 November 2020

Pentameric ligand gated ion channel GLIC in complex with tetramethylarsonium (TMAs)

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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