2r4r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2r4r.jpg|left|200px]]
[[Image:2r4r.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2r4r |SIZE=350|CAPTION= <scene name='initialview01'>2r4r</scene>, resolution 3.400&Aring;
+
The line below this paragraph, containing "STRUCTURE_2r4r", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ADRB2, ADRB2R, B2AR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2r4r| PDB=2r4r | SCENE= }}
-
|RELATEDENTRY=[[2r4s|2R4S]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4r OCA], [http://www.ebi.ac.uk/pdbsum/2r4r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r4r RCSB]</span>
+
-
}}
+
'''Crystal structure of the human beta2 adrenoceptor'''
'''Crystal structure of the human beta2 adrenoceptor'''
Line 39: Line 36:
[[Category: Thian, F S.]]
[[Category: Thian, F S.]]
[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
-
[[Category: g-protein coupled receptor]]
+
[[Category: G-protein coupled receptor]]
-
[[Category: glycoprotein]]
+
[[Category: Glycoprotein]]
-
[[Category: lipoprotein]]
+
[[Category: Lipoprotein]]
-
[[Category: palmitate]]
+
[[Category: Palmitate]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: receptor]]
+
[[Category: Receptor]]
-
[[Category: signaling protein]]
+
[[Category: Signaling protein]]
-
[[Category: transducer]]
+
[[Category: Transducer]]
-
[[Category: transmembrane helix]]
+
[[Category: Transmembrane helix]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:14:20 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:30 2008''
+

Revision as of 13:14, 4 May 2008

Image:2r4r.jpg

Template:STRUCTURE 2r4r

Crystal structure of the human beta2 adrenoceptor


Overview

Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters has been hindered by their low natural abundance, inherent structural flexibility, and instability in detergent solutions. Here we report a structure of the human beta2 adrenoceptor (beta2AR), which was crystallized in a lipid environment when bound to an inverse agonist and in complex with a Fab that binds to the third intracellular loop. Diffraction data were obtained by high-brilliance microcrystallography and the structure determined at 3.4 A/3.7 A resolution. The cytoplasmic ends of the beta2AR transmembrane segments and the connecting loops are well resolved, whereas the extracellular regions of the beta2AR are not seen. The beta2AR structure differs from rhodopsin in having weaker interactions between the cytoplasmic ends of transmembrane (TM)3 and TM6, involving the conserved E/DRY sequences. These differences may be responsible for the relatively high basal activity and structural instability of the beta2AR, and contribute to the challenges in obtaining diffraction-quality crystals of non-rhodopsin GPCRs.

About this Structure

2R4R is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor., Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK, Nature. 2007 Nov 15;450(7168):383-7. Epub 2007 Oct 21. PMID:17952055 Page seeded by OCA on Sun May 4 16:14:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r4r"
Personal tools