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2y67

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==New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation==
==New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation==
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<StructureSection load='2y67' size='340' side='right' caption='[[2y67]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='2y67' size='340' side='right'caption='[[2y67]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y67 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y67 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Y67 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N21:(2R)-2-[[4-[[4-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]PHENOXY]METHYL]PHENYL]SULFONYLAMINO]PENTANEDIOIC+ACID'>N21</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N21:(2R)-2-[[4-[[4-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]PHENOXY]METHYL]PHENYL]SULFONYLAMINO]PENTANEDIOIC+ACID'>N21</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uuo|2uuo]], [[2jfg|2jfg]], [[4uag|4uag]], [[2uag|2uag]], [[3uag|3uag]], [[1e0d|1e0d]], [[2vte|2vte]], [[2jff|2jff]], [[1eeh|1eeh]], [[2x5o|2x5o]], [[2wjp|2wjp]], [[2vtd|2vtd]], [[2y1o|2y1o]], [[1uag|1uag]], [[2jfh|2jfh]], [[2uup|2uup]], [[2y66|2y66]], [[2y68|2y68]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uuo|2uuo]], [[2jfg|2jfg]], [[4uag|4uag]], [[2uag|2uag]], [[3uag|3uag]], [[1e0d|1e0d]], [[2vte|2vte]], [[2jff|2jff]], [[1eeh|1eeh]], [[2x5o|2x5o]], [[2wjp|2wjp]], [[2vtd|2vtd]], [[2y1o|2y1o]], [[1uag|1uag]], [[2jfh|2jfh]], [[2uup|2uup]], [[2y66|2y66]], [[2y68|2y68]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanine--D-glutamate_ligase UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.9 6.3.2.9] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanine--D-glutamate_ligase UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.9 6.3.2.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y67 OCA], [http://pdbe.org/2y67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y67 RCSB], [http://www.ebi.ac.uk/pdbsum/2y67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y67 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2y67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y67 OCA], [http://pdbe.org/2y67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y67 RCSB], [http://www.ebi.ac.uk/pdbsum/2y67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y67 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Ecoli]]
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[[Category: Large Structures]]
[[Category: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase]]
[[Category: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase]]
[[Category: Blanot, D]]
[[Category: Blanot, D]]

Revision as of 12:36, 22 July 2020

New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation

PDB ID 2y67

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