2r6f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2r6f.jpg|left|200px]]
[[Image:2r6f.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2r6f |SIZE=350|CAPTION= <scene name='initialview01'>2r6f</scene>, resolution 3.200&Aring;
+
The line below this paragraph, containing "STRUCTURE_2r6f", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+1004'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+1005'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Residue+A+1006'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Residue+B+1007'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Residue+B+1008'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Residue+B+1009'>AC6</scene>, <scene name='pdbsite=AC7:Adp+Binding+Site+For+Residue+A+1000'>AC7</scene>, <scene name='pdbsite=AC8:Adp+Binding+Site+For+Residue+A+1001'>AC8</scene>, <scene name='pdbsite=AC9:Adp+Binding+Site+For+Residue+B+1002'>AC9</scene> and <scene name='pdbsite=BC1:Adp+Binding+Site+For+Residue+B+1003'>BC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= uvrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2r6f| PDB=2r6f | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r6f OCA], [http://www.ebi.ac.uk/pdbsum/2r6f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r6f RCSB]</span>
+
-
}}
+
'''Crystal Structure of Bacillus stearothermophilus UvrA'''
'''Crystal Structure of Bacillus stearothermophilus UvrA'''
Line 30: Line 27:
[[Category: Pakotiprapha, D.]]
[[Category: Pakotiprapha, D.]]
[[Category: Verdine, G L.]]
[[Category: Verdine, G L.]]
-
[[Category: abc atpase]]
+
[[Category: Abc atpase]]
-
[[Category: atp-binding cassette]]
+
[[Category: Atp-binding cassette]]
-
[[Category: cytoplasm]]
+
[[Category: Cytoplasm]]
-
[[Category: dna damage]]
+
[[Category: Dna damage]]
-
[[Category: dna excision]]
+
[[Category: Dna excision]]
-
[[Category: dna repair]]
+
[[Category: Dna repair]]
-
[[Category: dna-binding]]
+
[[Category: Dna-binding]]
-
[[Category: excision nuclease]]
+
[[Category: Excision nuclease]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: metal-binding]]
+
[[Category: Metal-binding]]
-
[[Category: nucleotide excision repair]]
+
[[Category: Nucleotide excision repair]]
-
[[Category: nucleotide-binding]]
+
[[Category: Nucleotide-binding]]
-
[[Category: sos response]]
+
[[Category: Sos response]]
-
[[Category: uvra]]
+
[[Category: Uvra]]
-
[[Category: zinc]]
+
[[Category: Zinc]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:19:20 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:59 2008''
+

Revision as of 13:19, 4 May 2008

Image:2r6f.jpg

Template:STRUCTURE 2r6f

Crystal Structure of Bacillus stearothermophilus UvrA


Overview

The nucleotide excision repair pathway corrects many structurally unrelated DNA lesions. Damage recognition in bacteria is performed by UvrA, a member of the ABC ATPase superfamily whose functional form is a dimer with four nucleotide-binding domains (NBDs), two per protomer. In the 3.2 A structure of UvrA from Bacillus stearothermophilus, we observe that the nucleotide-binding sites are formed in an intramolecular fashion and are not at the dimer interface as is typically found in other ABC ATPases. UvrA also harbors two unique domains; we show that one of these is required for interaction with UvrB, its partner in lesion recognition. In addition, UvrA contains three zinc modules, the number and ligand sphere of which differ from previously published models. Structural analysis, biochemical experiments, surface electrostatics, and sequence conservation form the basis for models of ATP-modulated dimerization, UvrA-UvrB interaction, and DNA binding during the search for lesions.

About this Structure

2R6F is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Bacillus stearothermophilus UvrA provides insight into ATP-modulated dimerization, UvrB interaction, and DNA binding., Pakotiprapha D, Inuzuka Y, Bowman BR, Moolenaar GF, Goosen N, Jeruzalmi D, Verdine GL, Mol Cell. 2008 Jan 18;29(1):122-33. Epub 2007 Dec 27. PMID:18158267 Page seeded by OCA on Sun May 4 16:19:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r6f"
Personal tools