2r6n

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[[Image:2r6n.jpg|left|200px]]
[[Image:2r6n.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2r6n |SIZE=350|CAPTION= <scene name='initialview01'>2r6n</scene>, resolution 1.950&Aring;
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The line below this paragraph, containing "STRUCTURE_2r6n", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CKE:1-{7-CYCLOHEXYL-6-[4-(4-METHYLPIPERAZIN-1-YL)BENZYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}METHANAMINE'>CKE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2r6n| PDB=2r6n | SCENE= }}
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|RELATEDENTRY=[[1u9v|1U9V]], [[1u9w|1U9W]], [[1u9x|1U9X]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r6n OCA], [http://www.ebi.ac.uk/pdbsum/2r6n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r6n RCSB]</span>
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}}
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'''Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K'''
'''Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K'''
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[[Category: Mathis, B.]]
[[Category: Mathis, B.]]
[[Category: Ramage, P.]]
[[Category: Ramage, P.]]
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[[Category: covalent bond to inhibitor]]
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[[Category: Covalent bond to inhibitor]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: lysosome]]
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[[Category: Lysosome]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: thiol protease]]
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[[Category: Thiol protease]]
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[[Category: zymogen]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:20:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:57:04 2008''
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Revision as of 13:20, 4 May 2008

Image:2r6n.jpg

Template:STRUCTURE 2r6n

Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K


Overview

Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.

About this Structure

2R6N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel scaffold for cathepsin K inhibitors., Teno N, Miyake T, Ehara T, Irie O, Sakaki J, Ohmori O, Gunji H, Matsuura N, Masuya K, Hitomi Y, Nonomura K, Horiuchi M, Gohda K, Iwasaki A, Umemura I, Tada S, Kometani M, Iwasaki G, Cowan-Jacob SW, Missbach M, Lattmann R, Betschart C, Bioorg Med Chem Lett. 2007 Nov 15;17(22):6096-100. Epub 2007 Sep 15. PMID:17911019 Page seeded by OCA on Sun May 4 16:20:09 2008

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OCA

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