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2r9y
From Proteopedia
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[[Image:2r9y.jpg|left|200px]] | [[Image:2r9y.jpg|left|200px]] | ||
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'''Structure of antiplasmin''' | '''Structure of antiplasmin''' | ||
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[[Category: Law, R H.P.]] | [[Category: Law, R H.P.]] | ||
[[Category: Whisstock, J C.]] | [[Category: Whisstock, J C.]] | ||
| - | [[Category: | + | [[Category: Acute phase]] |
| - | [[Category: | + | [[Category: Alpha2-antiplasmin]] |
| - | [[Category: | + | [[Category: Glycoprotein]] |
| - | [[Category: | + | [[Category: Hydrolase inhibitor]] |
| - | [[Category: | + | [[Category: Inhibitory serpin]] |
| - | [[Category: | + | [[Category: Plasmin inhibitor]] |
| - | [[Category: | + | [[Category: Protease inhibitor]] |
| - | [[Category: | + | [[Category: Secreted]] |
| - | [[Category: | + | [[Category: Serine protease inhibitor]] |
| - | [[Category: | + | [[Category: Sulfation]] |
| - | [[Category: | + | [[Category: Toxin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:30:19 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:30, 4 May 2008
Structure of antiplasmin
Overview
The serpin alpha(2)-antiplasmin (SERPINF2) is the principal inhibitor of plasmin and inhibits fibrinolysis. Accordingly, alpha(2)-antiplasmin deficiency in humans results in uncontrolled fibrinolysis and a bleeding disorder. alpha(2)-antiplasmin is an unusual serpin, in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. To understand how this may happen, we have determined the 2.65A X-ray crystal structure of an N-terminal truncated murine alpha(2)-antiplasmin. The structure reveals that part of the C-terminal sequence is tightly associated with the body of the serpin. This would be anticipated to position the flexible plasmin-binding portion of the C-terminus in close proximity to the serpin Reactive Center Loop where it may act as a template to accelerate serpin/protease interactions.
About this Structure
2R9Y is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin., Law RH, Sofian T, Kan WT, Horvath AJ, Hitchen CR, Langendorf CG, Buckle AM, Whisstock JC, Coughlin PB, Blood. 2008 Feb 15;111(4):2049-52. Epub 2007 Dec 6. PMID:18063751 Page seeded by OCA on Sun May 4 16:30:19 2008
