6fmf

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Current revision (05:13, 21 November 2024) (edit) (undo)
 
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==Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure==
==Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure==
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<StructureSection load='6fmf' size='340' side='right' caption='[[6fmf]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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<StructureSection load='6fmf' size='340' side='right'caption='[[6fmf]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6fmf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FMF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6fmf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FMF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUE:(2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic+acid'>DUE</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.811&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fmc|6fmc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUE:(2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic+acid'>DUE</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fmf OCA], [http://pdbe.org/6fmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fmf RCSB], [http://www.ebi.ac.uk/pdbsum/6fmf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fmf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fmf OCA], [https://pdbe.org/6fmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fmf RCSB], [https://www.ebi.ac.uk/pdbsum/6fmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fmf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NRP1_HUMAN NRP1_HUMAN]] The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
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[https://www.uniprot.org/uniprot/NRP1_HUMAN NRP1_HUMAN] The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6fmf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fmf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Neuropilin|Neuropilin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Djordjevic, S]]
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[[Category: Homo sapiens]]
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[[Category: Frankel, P]]
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[[Category: Large Structures]]
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[[Category: Selwood, D]]
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[[Category: Djordjevic S]]
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[[Category: Yelland, T]]
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[[Category: Frankel P]]
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[[Category: Zachary, I]]
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[[Category: Selwood D]]
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[[Category: Angiogenesis]]
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[[Category: Yelland T]]
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[[Category: Discoiding domain]]
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[[Category: Zachary I]]
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[[Category: Semaphorin signaling]]
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[[Category: Signaling protein]]
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[[Category: Small molecule inhibitor]]
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[[Category: Vegf signaling]]
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Current revision

Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure

PDB ID 6fmf

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