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3lbj

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Current revision (16:22, 1 November 2023) (edit) (undo)
 
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==Structure of human MDMX protein in complex with a small molecule inhibitor==
==Structure of human MDMX protein in complex with a small molecule inhibitor==
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<StructureSection load='3lbj' size='340' side='right' caption='[[3lbj]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='3lbj' size='340' side='right'caption='[[3lbj]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lbj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LBJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lbj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LBJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WW8:N-[(3S)-1-({6-CHLORO-3-[1-(4-CHLOROBENZYL)-4-PHENYL-1H-IMIDAZOL-5-YL]-1H-INDOL-2-YL}CARBONYL)PYRROLIDIN-3-YL]-N,N,N-TRIMETHYLPROPANE-1,3-DIAMINE'>WW8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3dab|3dab]], [[3lbk|3lbk]], [[3lbl|3lbl]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WW8:N-[(3S)-1-({6-CHLORO-3-[1-(4-CHLOROBENZYL)-4-PHENYL-1H-IMIDAZOL-5-YL]-1H-INDOL-2-YL}CARBONYL)PYRROLIDIN-3-YL]-N,N,N-TRIMETHYLPROPANE-1,3-DIAMINE'>WW8</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lbj OCA], [https://pdbe.org/3lbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lbj RCSB], [https://www.ebi.ac.uk/pdbsum/3lbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lbj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lbj OCA], [http://pdbe.org/3lbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lbj RCSB], [http://www.ebi.ac.uk/pdbsum/3lbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lbj ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
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[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Czarna, A]]
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[[Category: Large Structures]]
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[[Category: Holak, T A]]
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[[Category: Czarna A]]
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[[Category: Popowicz, G M]]
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[[Category: Holak TA]]
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[[Category: Wolf, S]]
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[[Category: Popowicz GM]]
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[[Category: Alternative splicing]]
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[[Category: Wolf S]]
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[[Category: Cell cycle]]
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[[Category: Inhibitor]]
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[[Category: Mdm2]]
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[[Category: Mdmx]]
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[[Category: Nucleus]]
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[[Category: P53]]
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[[Category: Polymorphism]]
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[[Category: Zinc-finger]]
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Current revision

Structure of human MDMX protein in complex with a small molecule inhibitor

PDB ID 3lbj

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