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5n2g

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Current revision (17:58, 8 November 2023) (edit) (undo)
 
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==Structure of the E9 DNA polymerase from vaccinia virus in complex with manganese==
==Structure of the E9 DNA polymerase from vaccinia virus in complex with manganese==
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<StructureSection load='5n2g' size='340' side='right' caption='[[5n2g]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
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<StructureSection load='5n2g' size='340' side='right'caption='[[5n2g]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccc Vaccc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n2g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Copenhagen Vaccinia virus Copenhagen]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N2G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">POL, E9L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10249 VACCC])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2g OCA], [http://pdbe.org/5n2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2g RCSB], [http://www.ebi.ac.uk/pdbsum/5n2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2g OCA], [https://pdbe.org/5n2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n2g RCSB], [https://www.ebi.ac.uk/pdbsum/5n2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPOL_VACCC DPOL_VACCC]] Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).
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[https://www.uniprot.org/uniprot/DPOL_VACCC DPOL_VACCC] Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Vaccc]]
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[[Category: Large Structures]]
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[[Category: Burmeister, W P]]
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[[Category: Vaccinia virus Copenhagen]]
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[[Category: Iseni, F]]
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[[Category: Burmeister WP]]
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[[Category: Tarbouriech, N]]
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[[Category: Iseni F]]
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[[Category: Dna polymerase]]
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[[Category: Tarbouriech N]]
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[[Category: Family b polymerase]]
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[[Category: Processivity factor]]
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[[Category: Protein-protein interface]]
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[[Category: Transferase]]
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[[Category: Vaccinia virus]]
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Current revision

Structure of the E9 DNA polymerase from vaccinia virus in complex with manganese

PDB ID 5n2g

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