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6d1r

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==Structure of Staphylococcus aureus RNase P protein at 2.0 angstrom==
==Structure of Staphylococcus aureus RNase P protein at 2.0 angstrom==
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<StructureSection load='6d1r' size='340' side='right' caption='[[6d1r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='6d1r' size='340' side='right'caption='[[6d1r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6d1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D1R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6d1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D1R FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rnpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.995&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1r OCA], [https://pdbe.org/6d1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d1r RCSB], [https://www.ebi.ac.uk/pdbsum/6d1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1r OCA], [http://pdbe.org/6d1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d1r RCSB], [http://www.ebi.ac.uk/pdbsum/6d1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1r ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RNPA_STAAU RNPA_STAAU]] RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
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[https://www.uniprot.org/uniprot/RNPA_STAAU RNPA_STAAU] RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Staphylococcus aureus ribonuclease-P-protein subunit (RnpA) is a promising antimicrobial target that is a key protein component for two essential cellular processes, RNA degradation and transfer-RNA (tRNA) maturation. The first crystal structure of RnpA from the pathogenic bacterial species, S. aureus, is reported at 2.0 A resolution. The structure presented maintains key similarities with previously reported RnpA structures from bacteria and archaea, including the highly conserved RNR-box region and aromatic residues in the precursor-tRNA 5'-leader-binding domain. This structure will be instrumental in the pursuit of structure-based designed inhibitors targeting RnpA-mediated RNA processing as a novel therapeutic approach for treating S. aureus infections.
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Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus.,Ha L, Colquhoun J, Noinaj N, Das C, Dunman PM, Flaherty DP Acta Crystallogr F Struct Biol Commun. 2018 Oct 1;74(Pt 10):632-637. doi:, 10.1107/S2053230X18011512. Epub 2018 Sep 19. PMID:30279314<ref>PMID:30279314</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6d1r" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Ribonuclease|Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ribonuclease P]]
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[[Category: Large Structures]]
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[[Category: Colquhoun, J]]
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[[Category: Staphylococcus aureus]]
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[[Category: Das, C]]
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[[Category: Colquhoun J]]
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[[Category: Dunman, P]]
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[[Category: Das C]]
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[[Category: Flaherty, D P]]
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[[Category: Dunman P]]
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[[Category: Ha, L]]
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[[Category: Flaherty DP]]
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[[Category: Noinaj, N]]
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[[Category: Ha L]]
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[[Category: P protein]]
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[[Category: Noinaj N]]
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[[Category: Rna binding protein]]
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[[Category: Rna metabolism]]
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[[Category: Rnase]]
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[[Category: Trna processing]]
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Current revision

Structure of Staphylococcus aureus RNase P protein at 2.0 angstrom

PDB ID 6d1r

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