2ytc
From Proteopedia
(Difference between revisions)
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==Solution structure of RNA binding domain in Pre-mRNA-splicing factor RBM22== | ==Solution structure of RNA binding domain in Pre-mRNA-splicing factor RBM22== | ||
| - | <StructureSection load='2ytc' size='340' side='right' caption='[[2ytc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2ytc' size='340' side='right'caption='[[2ytc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ytc]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ytc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YTC FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBM22 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBM22 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ytc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ytc OCA], [https://pdbe.org/2ytc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ytc RCSB], [https://www.ebi.ac.uk/pdbsum/2ytc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ytc ProSAT], [https://www.topsan.org/Proteins/RSGI/2ytc TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RBM22_HUMAN RBM22_HUMAN]] Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.<ref>PMID:17045351</ref> <ref>PMID:21122810</ref> <ref>PMID:22246180</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Pre-mRNA | + | *[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Inoue, M]] | [[Category: Inoue, M]] | ||
[[Category: Kasahara, N]] | [[Category: Kasahara, N]] | ||
Revision as of 07:13, 1 December 2021
Solution structure of RNA binding domain in Pre-mRNA-splicing factor RBM22
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