2reb

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[[Image:2reb.gif|left|200px]]
[[Image:2reb.gif|left|200px]]
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{{Structure
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|PDB= 2reb |SIZE=350|CAPTION= <scene name='initialview01'>2reb</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_2reb", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span>
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{{STRUCTURE_2reb| PDB=2reb | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2reb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2reb OCA], [http://www.ebi.ac.uk/pdbsum/2reb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2reb RCSB]</span>
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'''THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER'''
'''THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER'''
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[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
[[Category: Story, R M.]]
[[Category: Story, R M.]]
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[[Category: homologous recombination]]
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[[Category: Homologous recombination]]
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[[Category: self-cleavage stimulation]]
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[[Category: Self-cleavage stimulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:44:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:28 2008''
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Revision as of 13:44, 4 May 2008

Image:2reb.gif

Template:STRUCTURE 2reb

THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER


Overview

The crystal structure of the recA protein from Escherichia coli at 2.3-A resolution reveals a major domain that binds ADP and probably single- and double-stranded DNA. Two smaller subdomains at the N and C termini protrude from the protein and respectively stabilize a 6(1) helical polymer of protein subunits and interpolymer bundles. This polymer structure closely resembles that of recA/DNA filaments determined by electron microscopy. Mutations in recA protein that enhance coprotease, DNA-binding and/or strand-exchange activity can be explained if the interpolymer interactions in the crystal reflect a regulatory mechanism in vivo.

About this Structure

2REB is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of the E. coli recA protein monomer and polymer., Story RM, Weber IT, Steitz TA, Nature. 1992 Jan 23;355(6358):318-25. PMID:1731246 Page seeded by OCA on Sun May 4 16:44:16 2008

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