2zet

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==Crystal structure of the small GTPase Rab27B complexed with the Slp homology domain of Slac2-a/melanophilin==
==Crystal structure of the small GTPase Rab27B complexed with the Slp homology domain of Slac2-a/melanophilin==
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<StructureSection load='2zet' size='340' side='right' caption='[[2zet]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='2zet' size='340' side='right'caption='[[2zet]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zet]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZET FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zet]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZET FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rab27b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Slac2a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rab27b ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Slac2a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zet OCA], [http://pdbe.org/2zet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zet RCSB], [http://www.ebi.ac.uk/pdbsum/2zet PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zet ProSAT], [http://www.topsan.org/Proteins/RSGI/2zet TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zet OCA], [https://pdbe.org/2zet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zet RCSB], [https://www.ebi.ac.uk/pdbsum/2zet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zet ProSAT], [https://www.topsan.org/Proteins/RSGI/2zet TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RB27B_MOUSE RB27B_MOUSE]] May be involved in targeting uroplakins to urothelial apical membranes (By similarity). [[http://www.uniprot.org/uniprot/MELPH_MOUSE MELPH_MOUSE]] Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.<ref>PMID:11887186</ref>
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[[https://www.uniprot.org/uniprot/RB27B_MOUSE RB27B_MOUSE]] May be involved in targeting uroplakins to urothelial apical membranes (By similarity). [[https://www.uniprot.org/uniprot/MELPH_MOUSE MELPH_MOUSE]] Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.<ref>PMID:11887186</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2zet" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2zet" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Exophilin 3D structures|Exophilin 3D structures]]
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Fukuda, M]]
[[Category: Fukuda, M]]

Revision as of 07:15, 10 November 2021

Crystal structure of the small GTPase Rab27B complexed with the Slp homology domain of Slac2-a/melanophilin

PDB ID 2zet

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