Proteopedia:Featured SEL/1

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<tr><td><div class='scrolling'>'''Avian Influenza Neuraminidase'''<br>
<tr><td><div class='scrolling'>'''Avian Influenza Neuraminidase'''<br>
''Eric Martz''<br>
''Eric Martz''<br>
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H5N1 bird flu has seemed a likely pandemic threat for decades, but the first new influenza virus to emerge as an imminent pandemic threat in the 21st century is H1N1 swine flu. The drug oseltamivir (Tamiflu®) inhibits flu neuraminidase, a component necessary for virus spread, in susceptible flu strains. Luckily H1N1 swine flu is susceptible (at least in early May, 2009). The development of oseltamivir was guided, in part, by crystallographically determined structures of flu neuraminidase. Neuraminidase is a homotetramer, shown with oseltamivir bound. Oseltamivir was designed to fit N2/N9 (neuraminidases from other strains of flu). Serendipitously, it also fits N1, doing so by pulling one side of the binding site against itself (induced fit).
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The first new influenza virus to emerge as an imminent pandemic threat in the 21st century is H1N1 swine flu. The drug '''oseltamivir''' (Tamiflu®) inhibits flu neuraminidase, a component necessary for virus spread, in susceptible flu strains. The development of oseltamivir was guided, in part, by crystallographically determined structures of flu neuraminidase, which is a homotetramer, shown with oseltamivir bound. Oseltamivir was designed to fit N2/N9 (neuraminidases from other strains of flu). Serendipitously, it also fits N1 by induced fit.
>>> [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza|Visit this page]] >>>
>>> [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza|Visit this page]] >>>

Revision as of 18:49, 18 October 2018

Image:Anim Avian Influenza Neuraminidase.gif
Avian Influenza Neuraminidase

Eric Martz
The first new influenza virus to emerge as an imminent pandemic threat in the 21st century is H1N1 swine flu. The drug oseltamivir (Tamiflu®) inhibits flu neuraminidase, a component necessary for virus spread, in susceptible flu strains. The development of oseltamivir was guided, in part, by crystallographically determined structures of flu neuraminidase, which is a homotetramer, shown with oseltamivir bound. Oseltamivir was designed to fit N2/N9 (neuraminidases from other strains of flu). Serendipitously, it also fits N1 by induced fit.

>>> Visit this page >>>

Proteopedia Page Contributors and Editors (what is this?)

Angel Herraez, Jaime Prilusky

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