Proteopedia:Featured SEL/0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(shorten the content)
Line 3: Line 3:
<tr><td><div class='scrolling '>'''HIV-1 protease'''<br>
<tr><td><div class='scrolling '>'''HIV-1 protease'''<br>
''David Canner''<br>
''David Canner''<br>
-
The X-ray structure of HIV-1 protease reveals that it is composed of two symmetrically related subunits, each consisting of 99 amino acid residues. The subunits come together in such as way as to form a tunnel where they meet. This tunnel is of critical importance because the active site of the protease is located in its interior. The active site consists of two Asp-Thr-Gly conserved sequences, making it a member of the aspartyl protease family. The two Asp's are essential catalytic residues either interact with the incoming water OR protonate the carbonyl to make the carbon more electrophilic for the incoming water.
+
The X-ray structure of HIV-1 protease reveals that it is composed of two symmetrically related subunits which form a tunnel where they meet. This is critical because it contains the active site of the protease, consisting on two Asp-Thr-Gly conserved sequences, making it a member of the aspartyl protease family. The two catalytic Asp's either interact with the incoming water or protonate the carbonyl to make the carbon more electrophilic for the incoming water.
>>> [[Immunodeficiency virus protease|Visit this page]] >>>
>>> [[Immunodeficiency virus protease|Visit this page]] >>>

Revision as of 18:55, 18 October 2018

Image:Anim HIV protease.gif
HIV-1 protease

David Canner
The X-ray structure of HIV-1 protease reveals that it is composed of two symmetrically related subunits which form a tunnel where they meet. This is critical because it contains the active site of the protease, consisting on two Asp-Thr-Gly conserved sequences, making it a member of the aspartyl protease family. The two catalytic Asp's either interact with the incoming water or protonate the carbonyl to make the carbon more electrophilic for the incoming water.

>>> Visit this page >>>

Proteopedia Page Contributors and Editors (what is this?)

Angel Herraez, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Proteopedia:Featured_SEL/0"
Personal tools