RNA polymerase

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**[[1xpp]] – RNAP subunit L – ''Thermoplasma acidophilum'' <br />
**[[1xpp]] – RNAP subunit L – ''Thermoplasma acidophilum'' <br />
**[[2waq]], [[2wb1]], [[4ayb]] – SsRNAP <br />
**[[2waq]], [[2wb1]], [[4ayb]] – SsRNAP <br />
-
**[[3e7h]] – RNAP subunit β – ''Vibrio cholera''<br />
+
**[[3e7h]] – VcRNAP subunit β – ''Vibrio cholera''<br />
**[[1ef4]] – MtRNAP subunit RPB10 – ''Methanothermobacter thermautotrophicus''<br />
**[[1ef4]] – MtRNAP subunit RPB10 – ''Methanothermobacter thermautotrophicus''<br />
**[[1eik]] - MtRNAP subunit RPB5 – NMR<br />
**[[1eik]] - MtRNAP subunit RPB5 – NMR<br />
Line 242: Line 242:
**[[3spa]] - hRNAP + polypeptide <br />
**[[3spa]] - hRNAP + polypeptide <br />
 +
*''Eukaryotic DNA primase''
-
 
+
**[[4lik]], [[4mhk]] - hDNAP small subunit<br />
-
*''DNA primase''
+
-
 
+
-
**[[4lik]] - hDNAP small subunit<br />
+
-
**[[4lil]] - hDNAP small subunit + UTP<br />
+
**[[3q36]] – hDNAP large subunit<br />
**[[3q36]] – hDNAP large subunit<br />
**[[5i7m]] – hDNAP large subunit (mutant)<br />
**[[5i7m]] – hDNAP large subunit (mutant)<br />
 +
**[[3l9q]] – hDNAP large subunit P58C domain <br />
 +
**[[5dqo]] – hDNAP large subunit P58C domain (mutant)<br />
 +
**[[4rr2]] - hDNAP small + large subunit<br />
**[[4bpu]] - hDNAP small (mutant) + large subunit<br />
**[[4bpu]] - hDNAP small (mutant) + large subunit<br />
-
**[[4bpw]] - hDNAP small (mutant) + large subunit + UTP<br />
 
-
**[[4bpx]] - hDNAP small (mutant) + DNA polymerase α subunit<br />
 
**[[4ehs]] – HpDNAP C terminal<br />
**[[4ehs]] – HpDNAP C terminal<br />
-
**[[4lim]] - yDNAP small subunit<br />
+
**[[4lim]], [[4mm2]] - yDNAP small subunit<br />
**[[3lgb]] - yDNAP large subunit<br />
**[[3lgb]] - yDNAP large subunit<br />
-
*''Bacterial primase''
+
*''Eukaryotic DNA primase complex''
-
**[[2r6a]], [[2r6c]] - GsdnaG helicase binding domain + helicase – ''Geobacillus stearothermophilus''<br />
+
**[[4lil]] - hDNAP small subunit + UTP<br />
-
**[[4m4w]] - GsdnaG helicase binding domain + helicase + DnaI<br />
+
**[[5f0s]], [[5f0q]] – hDNAP large subunit C terminal + RNA<br />
-
**[[1d0q]] - GsDNAP zinc-binding domain<br />
+
**[[4bpw]] - hDNAP small (mutant) + large subunit + UTP<br />
 +
**[[4bpx]] - hDNAP small (mutant) + DNA polymerase α catalytic subunit<br />
 +
**[[5exr]] - hDNAP small + large subunits + DNA polymerase α catalytic subunit<br />
 +
 
 +
*''Bacterial DNA primase''
 +
 
 +
**[[1d0q]] - GsDNAP zinc-binding domain - ''Geobacillus stearothermophilus''<br />
**[[1z8s]] - GsdnaG dnaB binding domain - NMR<br />
**[[1z8s]] - GsdnaG dnaB binding domain - NMR<br />
**[[2haj]] - EcdnaG catalytic domain - NMR<br />
**[[2haj]] - EcdnaG catalytic domain - NMR<br />
-
**[[3b39]] – EcdnaG catalytic domain + DNA<br />
 
**[[1t3w]] – EcdnaG C-terminal<br />
**[[1t3w]] – EcdnaG C-terminal<br />
**[[1eqn]], [[1dd9]], [[1dde]] – EcdnaG catalytic core<br />
**[[1eqn]], [[1dd9]], [[1dde]] – EcdnaG catalytic core<br />
**[[5w33]] - MtudnaG <br />
**[[5w33]] - MtudnaG <br />
-
**[[5w36]], [[5w35]], [[5w34]] - MtudnaG + DNA<br />
 
**[[5vaz]] – dnaG – ''Pseudomonas aeruginosa'' <br />
**[[5vaz]] – dnaG – ''Pseudomonas aeruginosa'' <br />
 +
**[[4im9]] – VcdnaG C-terminal<br />
**[[3m1m]] – DNAP RNA polymerase domain – ''Sulfolobus islandicus''<br />
**[[3m1m]] – DNAP RNA polymerase domain – ''Sulfolobus islandicus''<br />
**[[1zt2]], [[2pa8]], [[2pmz]], [[3hkz]] - DNAP small + large subunit – ''Sulfolobus solfataricus''<br />
**[[1zt2]], [[2pa8]], [[2pmz]], [[3hkz]] - DNAP small + large subunit – ''Sulfolobus solfataricus''<br />
**[[2au3]] – DNAP zinc-binding and RNA polymerase domains – ''Aquifex aeolicus''<br />
**[[2au3]] – DNAP zinc-binding and RNA polymerase domains – ''Aquifex aeolicus''<br />
**[[1v33]] - PhDNAP small subunit – ''Pyrocuccus horikoshii''<br />
**[[1v33]] - PhDNAP small subunit – ''Pyrocuccus horikoshii''<br />
-
**[[1v34]] - PhDNAP small subunit + nucleotide<br />
 
**[[1g71]] - PfDNAP small subunit<br />
**[[1g71]] - PfDNAP small subunit<br />
**[[4e2k]] – SaDNAP – ''Staphylococcus aureus''<br />
**[[4e2k]] – SaDNAP – ''Staphylococcus aureus''<br />
-
**[[2lzn]] – SaDNAP C terminal – NMR<br />
+
**[[2lzn]] – SaDNAP C-terminal – NMR<br />
-
**[[4edg]], [[4edk]], [[4edr]], [[4edt]], [[4edv]], [[4ee1]] – SaDNAP + nucleotide
+
**[[5guj]] – BsdnaG RNAP domain <br />
 +
*''Bacterial DNA primase complex''
 +
**[[2r6a]], [[2r6c]] - GsdnaG helicase binding domain + helicase – ''Geobacillus stearothermophilus''<br />
 +
**[[4m4w]] - GsdnaG helicase binding domain + helicase + DnaI<br />
 +
**[[3b39]] – EcdnaG catalytic domain + DNA<br />
 +
**[[5w36]], [[5w35]], [[5w34]] - MtudnaG + DNA<br />
 +
**[[1v34]] - PhDNAP small subunit + UTP<br />
 +
**[[4edg]], [[4edk]], [[4edr]], [[4edt]], [[4edv]], [[4ee1]] – SaDNAP + nucleotide<br />
*''RNA polymerase from Bacteriophage T7''
*''RNA polymerase from Bacteriophage T7''

Revision as of 10:04, 21 October 2018

Yeast RNA polymerase II elongation complex C complexed with DNA and RNA and Zn+2 (grey) and Mg+2 (green) ions 3m3y. Subunit B1 (grey), B2 (green), B3 (pink), B9 (wheat), B11 (rust), ABC1 (magenta), ABC2 (cyan), ABC3 (red), ABC4 (aqua), ABC5 (blue) (PDB code 3m3y).

Drag the structure with the mouse to rotate

3D Structures of RNA polymerase

Updated on 21-October-2018


References

  1. ↑ Cramer P, Armache KJ, Baumli S, Benkert S, Brueckner F, Buchen C, Damsma GE, Dengl S, Geiger SR, Jasiak AJ, Jawhari A, Jennebach S, Kamenski T, Kettenberger H, Kuhn CD, Lehmann E, Leike K, Sydow JF, Vannini A. Structure of eukaryotic RNA polymerases. Annu Rev Biophys. 2008;37:337-52. doi: 10.1146/annurev.biophys.37.032807.130008. PMID:18573085 doi:http://dx.doi.org/10.1146/annurev.biophys.37.032807.130008
  2. ↑ Comai L. Mechanism of RNA polymerase I transcription. Adv Protein Chem. 2004;67:123-55. PMID:14969726 doi:http://dx.doi.org/10.1016/S0065-3233(04)67005-7
  3. ↑ Hahn S. Structure and mechanism of the RNA polymerase II transcription machinery. Nat Struct Mol Biol. 2004 May;11(5):394-403. PMID:15114340 doi:http://dx.doi.org/10.1038/nsmb763
  4. ↑ Longo DL, Herbert V. Radioassay for serum and red cell folate. J Lab Clin Med. 1976 Jan;87(1):138-51. PMID:1452
  5. ↑ Frick DN, Richardson CC. DNA primases. Annu Rev Biochem. 2001;70:39-80. PMID:11395402 doi:http://dx.doi.org/10.1146/annurev.biochem.70.1.39
  6. ↑ Naue N, Beerbaum M, Bogutzki A, Schmieder P, Curth U. The helicase-binding domain of Escherichia coli DnaG primase interacts with the highly conserved C-terminal region of single-stranded DNA-binding protein. Nucleic Acids Res. 2013 Apr;41(8):4507-17. doi: 10.1093/nar/gkt107. Epub 2013 Feb, 20. PMID:23430154 doi:http://dx.doi.org/10.1093/nar/gkt107
  7. ↑ Ahlquist P. RNA-dependent RNA polymerases, viruses, and RNA silencing. Science. 2002 May 17;296(5571):1270-3. PMID:12016304 doi:http://dx.doi.org/10.1126/science.1069132
  8. ↑ Fukushi S, Kojima S, Takai R, Hoshino FB, Oka T, Takeda N, Katayama K, Kageyama T. Poly(A)- and primer-independent RNA polymerase of Norovirus. J Virol. 2004 Apr;78(8):3889-96. PMID:15047805

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