2rko

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[[Image:2rko.jpg|left|200px]]
[[Image:2rko.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2rko |SIZE=350|CAPTION= <scene name='initialview01'>2rko</scene>, resolution 3.350&Aring;
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The line below this paragraph, containing "STRUCTURE_2rko", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= VPS4P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01078 Mg_chelatase], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00004 AAA], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam09336 Vps4_C], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00009 AAA]</span>
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{{STRUCTURE_2rko| PDB=2rko | SCENE= }}
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|RELATEDENTRY=[[1xwi|1XWI]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rko OCA], [http://www.ebi.ac.uk/pdbsum/2rko PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rko RCSB]</span>
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}}
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'''Crystal Structure of the Vps4p-dimer'''
'''Crystal Structure of the Vps4p-dimer'''
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[[Category: Gruetter, M G.]]
[[Category: Gruetter, M G.]]
[[Category: Hartmann, C.]]
[[Category: Hartmann, C.]]
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[[Category: aaa-atpase domain]]
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[[Category: Aaa-atpase domain]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: endosome]]
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[[Category: Endosome]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protein transport]]
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[[Category: Protein transport]]
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[[Category: transport]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:05:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:01:31 2008''
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Revision as of 14:05, 4 May 2008

Image:2rko.jpg

Template:STRUCTURE 2rko

Crystal Structure of the Vps4p-dimer


Overview

The vacuolar protein sorting (Vps) pathway, in which Vps4 class I AAA-ATPases play a central role, regulates growth factor receptors, immune response, and developmental signaling, and participates in tumor suppression, apoptosis, and retrovirus budding. We present the first atomic structure of the nucleotide-free yeast His(6)DeltaNVps4p dimer and its AMPPNP (5'-adenylyl-beta,gamma-imidodiphosphate)-bound tetradecamer, derived from a cryo electron microscopy map. Vps4p dimers form two distinct heptameric rings and accommodate AAA cassettes in a head-to-head-not in a head-to-tail-fashion as in class II AAA-ATPases. Our model suggests a mechanism for disassembling ESCRT (endosomal sorting complex required for transport) complexes by movements of substrate-binding domains located at the periphery of the tetradecamer during ATP hydrolysis in one ring, followed by translocation through the central pore and ATP hydrolysis in the second ring.

About this Structure

2RKO is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Vacuolar Protein Sorting: Two Different Functional States of the AAA-ATPase Vps4p., Hartmann C, Chami M, Zachariae U, de Groot BL, Engel A, Grutter MG, J Mol Biol. 2008 Jan 15;. PMID:18272179 Page seeded by OCA on Sun May 4 17:05:55 2008

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