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5y1j

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'''Unreleased structure'''
 
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The entry 5y1j is ON HOLD until Oct 27 2019
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==Crystal structure of human FXR in complex with a functional drug ligand==
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<StructureSection load='5y1j' size='340' side='right' caption='[[5y1j]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Lu, Y., Li, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5y1j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y1J FirstGlance]. <br>
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Description: Crystal structure of human FXR in complex with a functional drug ligand
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D5H:2-[[2-fluoranyl-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic+acid'>D5H</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y1j OCA], [http://pdbe.org/5y1j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y1j RCSB], [http://www.ebi.ac.uk/pdbsum/5y1j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y1j ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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== Function ==
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[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Li, Y]]
[[Category: Lu, Y]]
[[Category: Lu, Y]]
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[[Category: Li, Y]]
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[[Category: Complex]]
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[[Category: Nuclear protein]]

Revision as of 06:44, 31 October 2018

Crystal structure of human FXR in complex with a functional drug ligand

5y1j, resolution 2.00Å

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