This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6hxr
From Proteopedia
(Difference between revisions)
m (Protected "6hxr" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Human PARP16 (ARTD15) IN COMPLEX WITH EB-47== | |
| - | + | <StructureSection load='6hxr' size='340' side='right'caption='[[6hxr]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hxr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HXR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UHB:2-[4-[(2S,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]CARBONYLPIPERAZIN-1-YL]-N-(1-OXIDANYLIDENE-2,3-DIHYDROISOINDOL-4-YL)ETHANAMIDE'>UHB</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxr OCA], [http://pdbe.org/6hxr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxr RCSB], [http://www.ebi.ac.uk/pdbsum/6hxr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxr ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PAR16_HUMAN PAR16_HUMAN]] Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors.<ref>PMID:23103912</ref> <ref>PMID:22701565</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Karlberg, T]] | [[Category: Karlberg, T]] | ||
| - | [[Category: | + | [[Category: Pinto, A F]] |
[[Category: Schuler, H]] | [[Category: Schuler, H]] | ||
| + | [[Category: Thorsell, A G]] | ||
| + | [[Category: Adp-ribose]] | ||
| + | [[Category: Adp-ribosylation]] | ||
| + | [[Category: Artd15]] | ||
| + | [[Category: Eb-47]] | ||
| + | [[Category: Inhibitor complex]] | ||
| + | [[Category: Parp16]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 08:58, 30 October 2019
Human PARP16 (ARTD15) IN COMPLEX WITH EB-47
| |||||||||||
