2rmj

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[[Image:2rmj.jpg|left|200px]]
[[Image:2rmj.jpg|left|200px]]
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{{Structure
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|PDB= 2rmj |SIZE=350|CAPTION= <scene name='initialview01'>2rmj</scene>
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The line below this paragraph, containing "STRUCTURE_2rmj", creates the "Structure Box" on the page.
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|GENE= DDX58 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2rmj| PDB=2rmj | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmj OCA], [http://www.ebi.ac.uk/pdbsum/2rmj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rmj RCSB]</span>
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'''Solution structure of RIG-I C-terminal domain'''
'''Solution structure of RIG-I C-terminal domain'''
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[[Category: Takahasi, K.]]
[[Category: Takahasi, K.]]
[[Category: Yoneyama, M.]]
[[Category: Yoneyama, M.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: antiviral defense]]
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[[Category: Antiviral defense]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: helicase]]
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[[Category: Helicase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: immune response]]
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[[Category: Immune response]]
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[[Category: innate immunity]]
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[[Category: Innate immunity]]
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[[Category: interferon induction]]
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[[Category: Interferon induction]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: rna binding protein]]
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[[Category: Rna binding protein]]
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[[Category: rna-binding]]
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[[Category: Rna-binding]]
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[[Category: ubl conjugation]]
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[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:10:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:02:02 2008''
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Revision as of 14:10, 4 May 2008

Image:2rmj.jpg

Template:STRUCTURE 2rmj

Solution structure of RIG-I C-terminal domain


Overview

A DExD/H protein, RIG-I, is critical in innate antiviral responses by sensing viral RNA. Here we show that RIG-I recognizes two distinct viral RNA patterns: double-stranded (ds) and 5'ppp single-stranded (ss) RNA. The binding of RIG-I with dsRNA or 5'ppp ssRNA in the presence of ATP produces a common structure, as suggested by protease digestion. Further analyses demonstrated that the C-terminal domain of RIG-I (CTD) recognizes these RNA patterns and CTD coincides with the autorepression domain. Structural analysis of CTD by NMR spectroscopy in conjunction with mutagenesis revealed that the basic surface of CTD with a characteristic cleft interacts with RIG-I ligands. Our results suggest that the bipartite structure of CTD regulates RIG-I on encountering viral RNA patterns.

About this Structure

2RMJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses., Takahasi K, Yoneyama M, Nishihori T, Hirai R, Kumeta H, Narita R, Gale M Jr, Inagaki F, Fujita T, Mol Cell. 2008 Feb 29;29(4):428-40. Epub 2008 Jan 31. PMID:18242112 Page seeded by OCA on Sun May 4 17:10:46 2008

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