2seb

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[[Image:2seb.jpg|left|200px]]
[[Image:2seb.jpg|left|200px]]
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{{Structure
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|PDB= 2seb |SIZE=350|CAPTION= <scene name='initialview01'>2seb</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_2seb", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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{{STRUCTURE_2seb| PDB=2seb | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2seb OCA], [http://www.ebi.ac.uk/pdbsum/2seb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2seb RCSB]</span>
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'''X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II'''
'''X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II'''
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[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Zaller, D M.]]
[[Category: Zaller, D M.]]
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[[Category: complex (mhc class ii/superantigen)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:17:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:02:48 2008''
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Revision as of 14:17, 4 May 2008

Image:2seb.jpg

Template:STRUCTURE 2seb

X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II


Overview

Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC class II allele HLA-DR4. The charge of the amino acid at DRbeta71 in the peptide-binding site appears to be critical in discriminating DR molecules linked to increased disease susceptibility. We have determined the 2.5 A x-ray structure of the DR4 molecule with the strongest linkage to RA (DRB1*0401) complexed with a human collagen II peptide. Details of a predicted salt bridge between lysine DRbeta71 and aspartic acid at the P4 peptide position suggest how it may participate in both antigen binding and TCR activation. A model is proposed for the DR4 recognition of collagen II (261-273), an antigen immunodominant in human-transgenic mouse models of RA.

About this Structure

2SEB is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II., Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC, Immunity. 1997 Oct;7(4):473-81. PMID:9354468 Page seeded by OCA on Sun May 4 17:17:53 2008

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