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2sem

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[[Image:2sem.jpg|left|200px]]
[[Image:2sem.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sem OCA], [http://www.ebi.ac.uk/pdbsum/2sem PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2sem RCSB]</span>
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'''SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR'''
'''SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR'''
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[[Category: Turck, C W.]]
[[Category: Turck, C W.]]
[[Category: Zuckermann, R N.]]
[[Category: Zuckermann, R N.]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: peptoid]]
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[[Category: Peptoid]]
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[[Category: proline-rich motif]]
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[[Category: Proline-rich motif]]
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[[Category: protein-protein recognition]]
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[[Category: Protein-protein recognition]]
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[[Category: sh3 domain]]
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[[Category: Sh3 domain]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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Revision as of 14:18, 4 May 2008

Image:2sem.jpg

Template:STRUCTURE 2sem

SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR


Overview

Src homology 3 (SH3) and WW protein interaction domains bind specific proline-rich sequences. However, instead of recognizing critical prolines on the basis of side chain shape or rigidity, these domains broadly accepted amide N-substituted residues. Proline is apparently specifically selected in vivo, despite low complementarity, because it is the only endogenous N-substituted amino acid. This discriminatory mechanism explains how these domains achieve specific but low-affinity recognition, a property that is necessary for transient signaling interactions. The mechanism can be exploited: screening a series of ligands in which key prolines were replaced by nonnatural N-substituted residues yielded a ligand that selectively bound the Grb2 SH3 domain with 100 times greater affinity.

About this Structure

2SEM is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors., Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA, Science. 1998 Dec 11;282(5396):2088-92. PMID:9851931 Page seeded by OCA on Sun May 4 17:18:00 2008

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