2shp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2shp.gif|left|200px]]
[[Image:2shp.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2shp |SIZE=350|CAPTION= <scene name='initialview01'>2shp</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_2shp", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CAT:DODECANE-TRIMETHYLAMINE'>CAT</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2shp| PDB=2shp | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2shp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2shp OCA], [http://www.ebi.ac.uk/pdbsum/2shp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2shp RCSB]</span>
+
-
}}
+
'''TYROSINE PHOSPHATASE SHP-2'''
'''TYROSINE PHOSPHATASE SHP-2'''
Line 31: Line 28:
[[Category: Pluskey, S.]]
[[Category: Pluskey, S.]]
[[Category: Shoelson, S E.]]
[[Category: Shoelson, S E.]]
-
[[Category: insulin signaling]]
+
[[Category: Insulin signaling]]
-
[[Category: sh2 protein]]
+
[[Category: Sh2 protein]]
-
[[Category: tyrosine phosphatase]]
+
[[Category: Tyrosine phosphatase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:19:04 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:03:01 2008''
+

Revision as of 14:19, 4 May 2008

Image:2shp.gif

Template:STRUCTURE 2shp

TYROSINE PHOSPHATASE SHP-2


Overview

The structure of the SHP-2 tyrosine phosphatase, determined at 2.0 angstroms resolution, shows how its catalytic activity is regulated by its two SH2 domains. In the absence of a tyrosine-phosphorylated binding partner, the N-terminal SH2 domain binds the phosphatase domain and directly blocks its active site. This interaction alters the structure of the N-SH2 domain, disrupting its phosphopeptide-binding cleft. Conversely, interaction of the N-SH2 domain with phosphopeptide disrupts its phosphatase recognition surface. Thus, the N-SH2 domain is a conformational switch; it either binds and inhibits the phosphatase, or it binds phosphoproteins and activates the enzyme. Recognition of bisphosphorylated ligands by the tandem SH2 domains is an integral element of this switch; the C-terminal SH2 domain contributes binding energy and specificity, but it does not have a direct role in activation.

About this Structure

2SHP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tyrosine phosphatase SHP-2., Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE, Cell. 1998 Feb 20;92(4):441-50. PMID:9491886 Page seeded by OCA on Sun May 4 17:19:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2shp"
Personal tools