6gmg
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Structure of a glutamine donor mimicking inhibitory peptide shaped by the catalytic cleft of microbial transglutaminase== | ==Structure of a glutamine donor mimicking inhibitory peptide shaped by the catalytic cleft of microbial transglutaminase== | ||
| - | <StructureSection load='6gmg' size='340' side='right' caption='[[6gmg]], [[Resolution|resolution]] 2.25Å' scene=''> | + | <StructureSection load='6gmg' size='340' side='right'caption='[[6gmg]], [[Resolution|resolution]] 2.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6gmg]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6gmg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_mobaraensis Streptomyces mobaraensis] and [https://en.wikipedia.org/wiki/Streptomyces_mobaraensis_NBRC_13819_=_DSM_40847 Streptomyces mobaraensis NBRC 13819 = DSM 40847]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GMG FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gmg OCA], [https://pdbe.org/6gmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gmg RCSB], [https://www.ebi.ac.uk/pdbsum/6gmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gmg ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PAPI_STRMB PAPI_STRMB] Stress protein produced under hyperthermal stress conditions. Serves as a glutamine and lysine donor substrate for transglutaminase. Inhibits the cysteine proteases papain and bromelain as well as the bovine serine protease trypsin. Has hardly any or no effect on subtilisin, bovine chymotrypsin, proteinase K from T.album, transglutaminase-activating metalloproteinase (TAMEP) from S.mobaraensis, dispase from B.polymyxa, thermolysin from B.thermoproteolyticus or collagenase from C.histolyticum.<ref>PMID:21715969</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 21: | Line 23: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Streptomyces mobaraensis]] | [[Category: Streptomyces mobaraensis]] | ||
| - | [[Category: | + | [[Category: Streptomyces mobaraensis NBRC 13819 = DSM 40847]] |
| - | [[Category: | + | [[Category: Fuchsbauer HL]] |
| + | [[Category: Juettner NE]] | ||
| + | [[Category: Schmelz S]] | ||
| + | [[Category: Scrima A]] | ||
Current revision
Structure of a glutamine donor mimicking inhibitory peptide shaped by the catalytic cleft of microbial transglutaminase
| |||||||||||
