This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5jyy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (19:15, 20 September 2023) (edit) (undo)
 
Line 1: Line 1:
==Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses==
==Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses==
-
<StructureSection load='5jyy' size='340' side='right' caption='[[5jyy]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+
<StructureSection load='5jyy' size='340' side='right'caption='[[5jyy]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5jyy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5e6l 5e6l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYY FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5jyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5e6l 5e6l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYY FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PY:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-[(2-METHOXYETHYL)CARBAMOYL]-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>6PY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mwx|4mwx]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PY:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-[(2-METHOXYETHYL)CARBAMOYL]-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>6PY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 9INFA])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyy OCA], [https://pdbe.org/5jyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyy RCSB], [https://www.ebi.ac.uk/pdbsum/5jyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyy ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyy OCA], [http://pdbe.org/5jyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyy RCSB], [http://www.ebi.ac.uk/pdbsum/5jyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyy ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/R4NFR6_9INFA R4NFR6_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
+
[https://www.uniprot.org/uniprot/R4NFR6_9INFA R4NFR6_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 21:
==See Also==
==See Also==
-
*[[Neuraminidase|Neuraminidase]]
+
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Exo-alpha-sialidase]]
+
[[Category: Influenza A virus]]
-
[[Category: Bi, Y]]
+
[[Category: Large Structures]]
-
[[Category: Fu, L]]
+
[[Category: Bi Y]]
-
[[Category: Gao, G F]]
+
[[Category: Fu L]]
-
[[Category: Li, X]]
+
[[Category: Gao GF]]
-
[[Category: Li, Y]]
+
[[Category: Li X]]
-
[[Category: Lu, X]]
+
[[Category: Li Y]]
-
[[Category: Lv, X]]
+
[[Category: Lu X]]
-
[[Category: Qi, J]]
+
[[Category: Lv X]]
-
[[Category: Wu, Y]]
+
[[Category: Qi J]]
-
[[Category: Yan, J]]
+
[[Category: Wu Y]]
-
[[Category: Zhang, S]]
+
[[Category: Yan J]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
[[Category: Zhang S]]
-
[[Category: Neuraminidase inhibitor]]
+
-
[[Category: Tetravalent zanamivir]]
+

Current revision

Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses

PDB ID 5jyy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5jyy"
Personal tools